Bartholomew D. Brigidi

TL;DR: Empirical evidence is provided for the potentially protective role of robust reward-related neural responsiveness against reductions in PA that may occur in the wake of life stress and possibly vulnerability to depression precipitated by stressful life events.

TL;DR: Initial evidence is provided that structural alterations in corticocerebellar circuitry supporting core functions related to the basic integration, coordination and monitoring of information may contribute to a general liability for common mental disorders.

TL;DR: It is reported that the experience of child maltreatment independent of recent life stress, gender, and age is associated with reduced structural integrity of the uncinate fasciculus, a major white matter pathway between the amygdala and ventromedial prefrontal cortex, in young adults.

TL;DR: These findings suggest a novel biomarker linking cumulative stress exposure with the later experience of depressive symptoms, as well as examining psychophysiological interactions between the ventral striatum and other brain regions in relation to these stress variables.

TL;DR: It is demonstrated that in the presence of increased life stress, increased dlPFC activity is associated with lower mood and anxiety symptoms and clinical diagnoses, and this results encourage ongoing efforts to understand prefrontal executive control as a possible intervention target for improving emotion regulation in Mood and anxiety disorders.