Bastiaan Evers

TL;DR: Combined loss of E-cadherin and p53 resulted in accelerated development of invasive and metastatic mammary carcinomas, which show strong resemblance to human ILC.

TL;DR: It is found that the CRISPR technology performed best, with low noise, minimal off-target effects and consistent activity across reagents, with a traditional short hairpin RNA (shRNA)-based system for performing lethality screens.

TL;DR: The exquisite sensitivity of these cells to the PARP inhibitor AZD 2281, alone or in combination with cisplatin, provides strong support for AZD2281 as a novel targeted therapeutic against BRCA-deficient cancers.

TL;DR: The most advanced mouse models for BRCA1- and BrcA2-associated tumorigenesis mimic human disease to the extent that they can be used in studies addressing clinically relevant questions and to translate increasing knowledge of BRC a1 and BRCa2 biology into clinical practice.

TL;DR: Using multiple in vivo mouse models of liver cancer, treatment with combined inhibition of of CDC7 and mTOR results in a marked reduction of tumour growth, indicating that exploiting an induced vulnerability could be an effective treatment for liver cancer.