Jules Gadiot

TL;DR: This study aimed to determine the prognostic relevance of PD‐L1 expression for the survival of melanoma patients.

TL;DR: Using multiple in vivo mouse models of liver cancer, treatment with combined inhibition of of CDC7 and mTOR results in a marked reduction of tumour growth, indicating that exploiting an induced vulnerability could be an effective treatment for liver cancer.

TL;DR: By analyzing common insertion sites (CISs) isolated from 446 tumors, it is suggested that 234 CIS-targeted genes are also dysregulated in human colorectal cancers and that 20 CISs-containing genes are newly discovered modifiers of canonical Wnt signaling.

TL;DR: The findings reveal the dynamics and plasticity of distinct macrophage populations in the irradiated tumor microenvironment, which has translational relevance for enhancing the efficacy of standard-of-care treatment in gliomas.

TL;DR: This evaluation evaluated to which extent dual targeting of the MAPK and PI3K-Akt-mTOR pathways affects tumor immune infiltrates and whether it synergizes with PD-1 checkpoint blockade in a BRAFV600E/PTEN−/−-driven melanoma mouse model to provide a rationale for clinical testing of short-term BRAF + MEK inhibition in combination with immune checkpoint blockade.