Application of flow cytometry to industrial microbial bioprocesses

This invention relates to latex compositions that incorporate at least one bioactive component such as an antibacterial or antifungal agent, and methods for making and using such latex compositions. The latex compositions disclosed herein can be prepared by the emulsion polymerization of the latex component monomers in the presence of the at least one bioactive component.

Cationic latex as a carrier for bioactive ingredients and methods for making and using the same

A multilayer laminate wound dressing comprising a plurality of layers of preferably silver or silver-coated fibers in a woven fabric alternating with layers of nonconductive, preferably nonmetallic, fabric. Each layer preferably contains a different ratio of metalized to nonmetalized fibers. The metalized fibers are preferably made of or coated with silver. The dressing promotes healing by stimulating cellular de-differetiation, followed by cellular proliferation. The dressing also has antibacterial, antifungal and analgesic properties.

Multilayer laminate wound dressing

A method of expanding a population of cells, while at the same time inhibiting differentiation of the cells, the method includes the step of providing the cells with conditions for cell proliferation and, at the same time, for reducing a capacity of the cells in utilizing copper. The method can be executed both in-vivo and ex-vivo. A method of inducing differentiation in a population of cells, the method includes the step of providing the cells with a transition metal chelator which binds copper and which is effective in inducing cell differentiation.

Methods of controlling proliferation and differentiation of stem and progenitor cells

The present invention relates to a substrate having antimicrobial and/or antistatic properties Such properties are imparted by applying a coating or film formed from a cationically-charged polymer composition The polymer composition includes a noncationic ethylenically unsaturated monomer, an ethylenically unsaturated monomer capable of providing a cationic charge to the polymer composition, and a steric stabilization component incorporated into the cationically-charged polymer composition The present invention also relates to a polymeric material comprising a base polymer blended with the above cationically-charged polymer composition

Antimicrobial and antistatic polymers and methods of using such polymers on various substrates

The invention relates to antimicrobial polymers which are produced by copolymerising a monomer of formula (I) wherein R1= -H or -CH?3, R?2= a branched or unbranched aliphatic hydrocarbon radical with 1 to 5 carbon atoms, Y = NR?3R4, N+R3R4R5X-, R3, R4, R5? = a substituted or unsubstituted, branched or unbranched aliphatic or aromatic hydrocarbon radical with 1 to 50 carbon atoms, R?3, R4 and R5? being the same or different, and X-= CH3SO-4, NO-3, F?-, Cl-, Br-, I-, CH?3CH2-, NO2?-, NO-, CN-, SCN-, CNO-, ClO-, ClO?2-, ClO3-, ClO4-; with other aliphatically unsaturated monomers. The invention also relates to a method for producing said polymers. The monomers of formula (I) can be especially, benzophenone derivatives. The polymers can also be produced by graft copolymerisation of a substrate, whereby a covalently bonded coating is obtained on the substrate surface. The inventive antimicrobial polymers can be used as a microbicide coating on e.g., hygiene items or in the area of medicine, and in paints or protective coatings.

Copolymers of acryloyloxyalkylamino compounds

Fluorescent staining techniques were used to study the anti-microbial properties of aqueous suspensions of a novel, water insoluble amino functionalised polymer on three micro-organisms Pseudomonas fluorescens, Staphylococcus epidermidis and Saccharomyses cerevisiae. The mechanism of action was similar for each organism in that, after various contact times with the polymer, a progressive change in individual cell physiological state was measured using multi-parameter flow cytometry. The microbiocidal activity of this polymer may be similar to that of substances referred to as polycationic, amphipathic compounds (peptides, peptide derivatives and other polyamines).

A study into the anti-microbial properties of an amino functionalised polymer using multi-parameter flow cytometry.

Antimicrobial copolymers of amino-functionalised alkyl or aryl (meth)acrylates or (meth)acrylamides (I) with alkyl or aryl (meth)acrylates or (meth)acrylamides (II), are new. Antimicrobial copolymers (AMC), obtained by copolymerisation of alkyl or aryl (meth)acrylate or (meth)acrylamide monomers of formula (I) and alkyl or aryl (meth)acrylates or (meth)acrylamides of formula (II), are new. R , R = H or methyl; R -R , R , R = optionally substituted, optionally branched 1-50C aliphatic or aromatic hydrocarbyl; X = O, NH or NR , and Y = O, NH or NR . Independent claims are also included for the following: (1) antimicrobial polymer blends containing AMC and other polymer(s), and (2) production of AMC.

New antimicrobial copolymers used for disinfection of water or production of microbicidal coatings, obtained by copolymerisation of amino-functional acrylate or acrylamide with non-functionalised monomers

The invention relates to antimicrobial copolymers or their polymer blends of formulae (I) and (II), with R1, R6 = -H or -CH?3, R2, R3, R4, R5, R7, R8? = a substituted or unsubstituted, branched or unbranched aliphatic or aromatic hydrocarbon radical with 1 to 50 carbon atoms, each the same or different, X = O, NH, NR5, Y = O, NH, NR8. Said antimicrobial copolymers or polymer blends can be used as a microbicidal coating for substrates and in paints or protective paint coatings. The invention also relates to a method for disinfecting water circuits using the antimicrobial copolymers or blends.

Antimicrobial, aminofunctionalised copolymers

The invention relates to a method for the antimicrobial treatment of surfaces by applying thermally assisted antimicrobial active polymers onto said surfaces.

Beate Kossmann

Papers

Copolymers of acryloyloxyalkylamino compounds

A study into the anti-microbial properties of an amino functionalised polymer using multi-parameter flow cytometry.

New antimicrobial copolymers used for disinfection of water or production of microbicidal coatings, obtained by copolymerisation of amino-functional acrylate or acrylamide with non-functionalised monomers

Antimicrobial, aminofunctionalised copolymers

Method for thermally assisted antimicrobial surface treatment