Beatriz Bosch

TL;DR: Findings suggest that most DTI-derived changes in AD and a-MCI are largely secondary to gray matter atrophy, however, specific DR signal increases in posterior parts of the inferior fronto-occipital and longitudinal fasciculi may reflect early WM compromise in preclinical dementia, which is independent of atrophy.

TL;DR: Although serial studies on late event-related potentials (ERPs) in healthy elders or MCI patients are inconclusive, others tracking disease progression and effects of cholinesterase inhibiting drugs in AD, and cross-sectional including MCI or predicting development of AD offer preliminary evidence of validity as a marker of disease progression from the MCI stage.

TL;DR: To design and validate a new screening test for amnestic Mild Cognitive Impairment (A‐MCI) and early stage Alzheimer's disease (AD).

TL;DR: Evidence is provided that the neurofunctional reorganizations related to CR among a-MCI and AD patients can be seen even when considering a preserved cognitive domain, being independent of gray matter atrophy.

TL;DR: At early preclinical stages, CTh in the precuneus and parietotemporal regions and caudate volume increase in PSEN1 MC and decrease thereafter with disease progression and the different trends in MD in asymptomatic and symptomatic MC suggest that different microstructural changes underlie the contrasting morphometric findings.