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Bei Ping He
Researcher at Robarts Research Institute
Publications - 8
Citations - 581
Bei Ping He is an academic researcher from Robarts Research Institute. The author has contributed to research in topics: Amyotrophic lateral sclerosis & Motor neuron. The author has an hindex of 6, co-authored 8 publications receiving 557 citations. Previous affiliations of Bei Ping He include University of Western Ontario.
Papers
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Journal ArticleDOI
High Threshold for Induction of the Stress Response in Motor Neurons Is Associated with Failure to Activate HSF1
Zarah Batulan,Gayle A. Shinder,Sandra Minotti,Bei Ping He,Mohammad M. Doroudchi,Josephine Nalbantoglu,Michael J. Strong,Heather D. Durham +7 more
TL;DR: The results indicate that the high threshold for induction of the stress response in motor neurons stems from an impaired ability to activate the main heat shock–stress sensor, HSF1.
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Characterization of Neuronal Intermediate Filament Protein Expression in Cervical Spinal Motor Neurons in Sporadic Amyotrophic Lateral Sclerosis (ALS)
TL;DR: This paper showed that the stoichiometry of cytoskeletal protein expression in ALS spinal motor neurons is significantly altered in a pattern conducive to the formation of neurofilamentous aggregates.
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Activated microglia (BV-2) facilitation of TNF-α-mediated motor neuron death in vitro
TL;DR: It is observed a 20-fold increase in the amount of TNF-α required to kill NSC-34 cells in the absence of LPS-activated BV-2 cell supernatant, indicating that microglia secrete factor(s) that facilitate T NF-α-mediated motor neuron death in vitro.
Journal ArticleDOI
NMDA induces NOS 1 translocation to the cell membrane in NGF-differentiated PC 12 cells.
TL;DR: The data validate that NGF-differentiated PC12 cells may be employed as a useful in vitro model to further study the regulation of NOS1 subsequent to NMDAR activation and indicate that NMDar activation also mediates NOS 1 targeting to the membrane.
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A morphological analysis of the motor neuron degeneration and microglial reaction in acute and chronic in vivo aluminum chloride neurotoxicity.
Bei Ping He,Michael J. Strong +1 more
TL;DR: It is demonstrated that microglial activation in vivo is inhibited by AlCl3 exposure, and that a correlation exists between the extent of microglia suppression and the potential for recovery, which suggests that microGlial activation is an important determinant of neuronal injury.