J
Josephine Nalbantoglu
Researcher at Montreal Neurological Institute and Hospital
Publications - 99
Citations - 5257
Josephine Nalbantoglu is an academic researcher from Montreal Neurological Institute and Hospital. The author has contributed to research in topics: Duchenne muscular dystrophy & Dystrophin. The author has an hindex of 39, co-authored 99 publications receiving 5090 citations. Previous affiliations of Josephine Nalbantoglu include University of Western Ontario & McGill University.
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Journal ArticleDOI
Apolipoprotein E4 allele as a predictor of cholinergic deficits and treatment outcome in Alzheimer disease.
Judes Poirier,Marie Claude Delisle,Rémi Quirion,Isabelle Aubert,Martin R. Farlow,Debmoi Lahiri,Siu Hui,Philippe Bertrand,Josephine Nalbantoglu,Brian M. Gilfix,Serge Gauthier +10 more
TL;DR: The concept that apoE4 plays a crucial role in the cholinergic dysfunction associated with AD and may be a prognostic indicator of poor response to therapy with acetylcholinesterase inhibitors in AD patients is strongly supported.
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Impaired learning and LTP in mice expressing the carboxy terminus of the Alzheimer amyloid precursor protein
Josephine Nalbantoglu,G Tirado-Santiago,A Lahsaïni,Judes Poirier,O Goncalves,G Verge,F Momoli,S A Welner,Guy Massicotte,Jean-Pierre Julien,M L Shapiro +10 more
TL;DR: Transgenic mice expressing the amyloidogenic carboxy-terminal 104 amino acids of APP develop, with ageing, extracellular β-amyloid immunoreactivity, increased gliosis and microglial reactivity, as well as cell loss hi the CA1 region of the hippocampus, indicating that alterations in the processing of APP may have considerable physiological effects on synaptic plasticity.
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High Threshold for Induction of the Stress Response in Motor Neurons Is Associated with Failure to Activate HSF1
Zarah Batulan,Gayle A. Shinder,Sandra Minotti,Bei Ping He,Mohammad M. Doroudchi,Josephine Nalbantoglu,Michael J. Strong,Heather D. Durham +7 more
TL;DR: The results indicate that the high threshold for induction of the stress response in motor neurons stems from an impaired ability to activate the main heat shock–stress sensor, HSF1.
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IRE1 Signaling Is Essential for Ischemia-Induced Vascular Endothelial Growth Factor-A Expression and Contributes to Angiogenesis and Tumor Growth In vivo
Benjamin Drogat,Patrick Auguste,Duc Thang Nguyên,Marion Bouchecareilh,Raphael Pineau,Josephine Nalbantoglu,Randal J. Kaufman,Eric Chevet,Andreas Bikfalvi,Michel Moenner +9 more
TL;DR: An essential role for IRE1-dependent signaling pathways in response to ischemia is suggested and this protein is identified as a potential therapeutic target to control both the angiogenic switch and tumor development.
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Neutral endopeptidase can hydrolyze β-amyloid(1–40) but shows no effect on β-amyloid precursor protein metabolism
TL;DR: High performance liquid chromatographic analyses of incubations of β-amyloid with neutral endopeptidase revealed at least nine product peaks, indicating that neutral endopesidedase can cleave β- amyloid at multiple sites.