B
Benedikt Simbrunner
Researcher at Medical University of Vienna
Publications - 117
Citations - 902
Benedikt Simbrunner is an academic researcher from Medical University of Vienna. The author has contributed to research in topics: Medicine & Internal medicine. The author has an hindex of 9, co-authored 45 publications receiving 251 citations. Previous affiliations of Benedikt Simbrunner include University of Vienna.
Papers
More filters
Journal ArticleDOI
Systemic inflammation increases across distinct stages of advanced chronic liver disease and correlates with decompensation and mortality.
Dalila Costa,Benedikt Simbrunner,Mathias Jachs,Lukas Hartl,David Bauer,Rafael Paternostro,Philipp Schwabl,Bernhard Scheiner,Albert Friedrich Stättermayer,Matthias Pinter,Michael Trauner,Mattias Mandorfer,Thomas Reiberger +12 more
TL;DR: HVPG progression occurs mostly in cACLD patients, while systemic inflammation as reflected by IL-6 levels increases within substantially only across dACLD stages, according to a single-center, prospective cohort of ACLD patients.
Journal ArticleDOI
Gut-liver axis signaling in portal hypertension.
TL;DR: The activation of the farnesoid X receptor in the liver and the gut was associated with beneficial effects in animal experiments, however, further studies regarding efficacy and safety of pharmacological FXR modulation in patients with ACLD are needed.
Journal ArticleDOI
Amelioration of systemic inflammation in advanced chronic liver disease upon beta-blocker therapy translates into improved clinical outcomes.
Mathias Jachs,Lukas Hartl,Dunja Schaufler,Christopher Desbalmes,Benedikt Simbrunner,Ernst Eigenbauer,David Bauer,Rafael Paternostro,Philipp Schwabl,Bernhard Scheiner,Theresa Bucsics,Albert Friedrich Stättermayer,Matthias Pinter,Michael Trauner,Mattias Mandorfer,Thomas Reiberger +15 more
TL;DR: NSBB therapy seems to exert systemic anti-inflammatory activity as evidenced by reductions of WBC and CRP levels, and this effect was most pronounced in Child-C and independent of HVPG response.
Journal ArticleDOI
Does the Functional Liver Imaging Score Derived from Gadoxetic Acid-enhanced MRI Predict Outcomes in Chronic Liver Disease?
Nina Bastati,Lucian Beer,Mattias Mandorfer,Sarah Poetter-Lang,Dietmar Tamandl,Yesim Bican,Michael Christoph Elmer,Henrik Einspieler,Georg Semmler,Benedikt Simbrunner,Michael Weber,Jacqueline C. Hodge,Federica Vernuccio,Claude B. Sirlin,Thomas Reiberger,Ahmed Ba-Ssalamah +15 more
TL;DR: The functional liver imaging score derived from gadoxetic acid-enhanced MRI identified patients with advanced chronic liver disease who are at increased risk for a first hepatic decompensation and for mortality.
Journal ArticleDOI
A salt bridge linking the first intracellular loop with the C terminus facilitates the folding of the serotonin transporter.
Florian Koban,Ali El-Kasaby,Ali El-Kasaby,Cornelia Häusler,Thomas Stockner,Benedikt Simbrunner,Harald H. Sitte,Michael Freissmuth,Sonja Sucic +8 more
TL;DR: Observations support a mechanistic model where the C-terminal amphipathic helix is stabilized by an intramolecular salt bridge between residues Glu615 and Arg152, which acts as a pivot in the conformational search associated with folding of SERT.