B
Benjamin F. Cravatt
Researcher at Scripps Research Institute
Publications - 698
Citations - 69790
Benjamin F. Cravatt is an academic researcher from Scripps Research Institute. The author has contributed to research in topics: Fatty acid amide hydrolase & Anandamide. The author has an hindex of 131, co-authored 666 publications receiving 61932 citations. Previous affiliations of Benjamin F. Cravatt include Pfizer & Indiana University.
Papers
More filters
Journal ArticleDOI
Molecular characterization of an enzyme that degrades neuromodulatory fatty-acid amides
Benjamin F. Cravatt,Dan K. Giang,Stephen P. Mayfield,Dale L. Boger,Richard A. Lerner,Norton B. Gilula +5 more
TL;DR: It is shown that oleamide hydrolase may serve as the general inactivating enzyme for a growing family of bioactive signalling molecules, the fatty-acid amides6–8, and the structure and sleep-inducing properties of cis-9-octadecenamide, a lipid isolated from the cerebrospinal fluid of sleep-deprived cats are reported.
Journal ArticleDOI
Quantitative reactivity profiling predicts functional cysteines in proteomes
Eranthie Weerapana,Chu Wang,Gabriel M. Simon,Florian Richter,Sagar D. Khare,Myles B. D. Dillon,Daniel A. Bachovchin,Kerri A. Mowen,David Baker,Benjamin F. Cravatt +9 more
TL;DR: It is demonstrated that quantitative reactivity profiling can form the basis for screening and functional assignment of cysteines in computationally designed proteins, where it discriminated catalytically active from inactive cysteine hydrolase designs.
Journal ArticleDOI
Supersensitivity to anandamide and enhanced endogenous cannabinoid signaling in mice lacking fatty acid amide hydrolase
Benjamin F. Cravatt,Kristin Demarest,Matthew P. Patricelli,Michael H. Bracey,Dan K. Giang,Billy R. Martin,Aron H. Lichtman +6 more
TL;DR: Results indicate that FAAH is a key regulator of anandamide signaling in vivo, setting an endogenous cannabinoid tone that modulates pain perception, and may represent an attractive pharmaceutical target for the treatment of pain and neuropsychiatric disorders.
Journal ArticleDOI
Activity-Based Protein Profiling: From Enzyme Chemistry to Proteomic Chemistry
TL;DR: Activity-based protein profiling (ABPP) has emerged as a powerful chemical proteomic strategy to characterize enzyme function directly in native biological systems on a global scale as mentioned in this paper, and the basic technology of ABPP, the enzyme classes addressable by this method, and the biological discoveries attributable to its application.
Journal ArticleDOI
A Comprehensive Profile of Brain Enzymes that Hydrolyze the Endocannabinoid 2-Arachidonoylglycerol
TL;DR: It is revealed that approximately 85% of brain 2-AG hydrolase activity can be ascribed to MAGL, and that the remaining 15% is mostly catalyzed by two uncharacterized enzymes, ABHD6 and ABHD12.