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Benjamin F. Cravatt
Researcher at Scripps Research Institute
Publications - 698
Citations - 69790
Benjamin F. Cravatt is an academic researcher from Scripps Research Institute. The author has contributed to research in topics: Fatty acid amide hydrolase & Anandamide. The author has an hindex of 131, co-authored 666 publications receiving 61932 citations. Previous affiliations of Benjamin F. Cravatt include Pfizer & Indiana University.
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TRIAZOLE DAGL(α) INHIBITORS
Benjamin F. Cravatt,Daisuke Ogasawara,Andreu Viader,Hui Deng,Tom van der Wel,Marcelis van der Stelt +5 more
TL;DR: In this paper, triazole compounds and pharmaceutical compositions comprising said compounds useful as modulators of DAGL(α) and DAGl(β) are presented and used for the treatment of neurodegenerative or neuroinflammatory disease.
Journal ArticleDOI
Resin-based investigation of acyl carrier protein interaction networks in Escherichia coli
TL;DR: A resin-based technique is demonstrated that leverages the unique tools for acyl carrier protein (ACP) modification with non-hydrolyzable linkages for investigation of protein interaction networks with the changing identity of a given protein target.
Posted ContentDOI
ABHD17 enzymes regulate dynamic plasma membrane palmitoylation and N-Ras-dependent cancer growth
Remsberg,Radu M. Suciu,Zambetti Na,Hanigan Tw,Firestone Aj,Inguva A,Anthony D. Long,Nhi Ngo,Kenneth M. Lum,Cassandra L. Henry,Stewart K. Richardson,Predovic M,Bihua Huang,Amy R. Howell,Micah J. Niphakis,Kevin Shannon,Benjamin F. Cravatt +16 more
TL;DR: ABD957 produced partial effects on N-Ras palmitoylation compared to Palmostatin M, but was much more selective across the proteome, reflecting a plasma membrane-delineated action on dynamically palMIToylated proteins.
Posted ContentDOI
Assigning functionality to cysteines by base editing of cancer dependency genes
Haoxin Li,Jarrett R. Remsberg,Sang Joon Won,Kevin T. Zhao,Tony P. Huang,Bingwen Lu,Gabriel M. Simon,David R. Liu,Benjamin F. Cravatt +8 more
TL;DR: In this article , a base-editing strategy was proposed to infer the functionality of cysteines by quantifying the impact of their missense mutation on cell proliferation, and the resulting atlas was used to identify essential, ligandable cysteine on >110 cancer dependency proteins.
Journal ArticleDOI
Ligands in crystal structures that aid in functional characterization
TL;DR: An overview and commentary on the value of liganded structures emerging from the JCSG structural genomics initiative.