B
Benjamin F. Cravatt
Researcher at Scripps Research Institute
Publications - 698
Citations - 69790
Benjamin F. Cravatt is an academic researcher from Scripps Research Institute. The author has contributed to research in topics: Fatty acid amide hydrolase & Anandamide. The author has an hindex of 131, co-authored 666 publications receiving 61932 citations. Previous affiliations of Benjamin F. Cravatt include Pfizer & Indiana University.
Papers
More filters
Journal ArticleDOI
Genomics and proteomics: From genes to function: advances in applications of chemical and systems biology
TL;DR: Matthew Bogyo's research interests focus on the use of small molecules to study the functional roles of proteases in human diseases, with an emphasis on cancer and malaria.
Journal ArticleDOI
ABHD4 regulates multiple classes of N-acyl phospholipids in the mammalian central nervous system.
TL;DR: ABHD4(-/-) mice are described and characterization using untargeted lipidomics are described to discover that ABHD4 regulates multiple classes of brain N-acyl phospholipids, designated as a principal regulator of N-ACYlospholipid metabolism in the mammalian nervous system.
Journal ArticleDOI
Omega-3 fatty acid epoxides are autocrine mediators that control the magnitude of IgE-mediated mast cell activation.
Yuta Shimanaka,Nozomu Kono,Nozomu Kono,Yoshitaka Taketomi,Yoshitaka Taketomi,Makoto Arita,Yoshimichi Okayama,Yuki Tanaka,Yasumasa Nishito,Tatsuki Mochizuki,Hiroyuki Kusuhara,Alexander Adibekian,Benjamin F. Cravatt,Makoto Murakami,Makoto Murakami,Makoto Murakami,Hiroyuki Arai,Hiroyuki Arai +17 more
TL;DR: The PAF-AH2–ω-3 epoxide–Srcin1 axis presents new potential drug targets for allergic diseases because of its role in promoting IgE-mediated activation of mast cells and attenuated mast cell activation and anaphylaxis following FcɛRI cross-linking.
Journal ArticleDOI
Peptide probes detect misfolded transthyretin oligomers in plasma of hereditary amyloidosis patients.
Joseph D. Schonhoft,Cecília Monteiro,Lars Plate,Yvonne S. Eisele,John M. Kelly,Daniel Boland,Christopher G. Parker,Benjamin F. Cravatt,Sergio Teruya,Stephen Helmke,Mathew S. Maurer,John L. Berk,Yoshiki Sekijima,Marta Novais,Teresa Coelho,Evan T. Powers,Jeffery W. Kelly +16 more
TL;DR: The authors used peptide-based probes to identify misfolded transthyretin (TTR) oligomers in the plasma of TTR hereditary amyloidosis patients exhibiting a predominant neuropathic phenotype.
Journal ArticleDOI
Direct Access to Versatile Electrophiles via Catalytic Oxidative Cyanation of Alkenes.
De-Wei Gao,Ekaterina V. Vinogradova,Sri Krishna Nimmagadda,Jose M. Medina,Yiyang Xiao,Radu M. Suciu,Benjamin F. Cravatt,Keary M. Engle +7 more
TL;DR: In this article, a catalytic, regioselective oxidative cyanation of conjugated and non-conjugated alkenes using a homogeneous copper catalyst and a bystanding N-F oxidant is reported.