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Benjamin Kirsch
Researcher at Kaiserslautern University of Technology
Publications - 179
Citations - 1762
Benjamin Kirsch is an academic researcher from Kaiserslautern University of Technology. The author has contributed to research in topics: Machining & Grinding. The author has an hindex of 16, co-authored 148 publications receiving 1171 citations. Previous affiliations of Benjamin Kirsch include Daimler AG & University of California, Davis.
Papers
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Journal ArticleDOI
Discovery of Antagonists of PqsR, a Key Player in 2-Alkyl-4-quinolone-Dependent Quorum Sensing in Pseudomonas aeruginosa
Cenbin Lu,Benjamin Kirsch,Christina Zimmer,Johannes C. de Jong,Claudia Henn,Christine K. Maurer,Mathias Müsken,Susanne Häussler,Anke Steinbach,Rolf W. Hartmann +9 more
TL;DR: In vitro evaluation using a reporter gene assay in Escherichia coli led to the discovery of the first competitive PqsR antagonists, which are highly potent (K(d,app) of compound 20: 7 nM).
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Sustainability of abrasive processes
TL;DR: In this article, the authors present an overview of research on sustainability of abrasive processes, which includes environmental, social, and economic sustainability in accordance with the definition proposed in the Brundtland Report of the United Nations.
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Kinematic simulation of high-performance grinding for analysis of chip parameters of single grains
Jan C. Aurich,Benjamin Kirsch +1 more
TL;DR: In this paper, a comprehensive view on a kinematic simulation of the grinding process (KSIM) is given, which is able to compute and evaluate chip parameters of each grain participating in the material removal process.
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Identification of small-molecule antagonists of the Pseudomonas aeruginosa transcriptional regulator PqsR: biophysically guided hit discovery and optimization.
Tobias Klein,Claudia Henn,Johannes C. de Jong,Christina Zimmer,Benjamin Kirsch,Christine K. Maurer,Dominik Pistorius,Rolf Müller,Anke Steinbach,Rolf W. Hartmann +9 more
TL;DR: The identified PqsR antagonists are promising scaffolds for further drug design efforts against this important pathogen and provide insights into the energetic characteristics of protein-ligand interactions.
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Selective laser melting (SLM) of AISI 316L—impact of laser power, layer thickness, and hatch spacing on roughness, density, and microhardness at constant input energy density
TL;DR: In this paper, a workpiece was manufactured by selective laser melting (SLM) with varying laser power, layer thickness, and hatch spacing, and it was found that the microhardness of an additively manufactured material correlates with its relative density.