Benjamin Philipson

TL;DR: This review summarizes recent discoveries about the molecular basis of the uniporter complex, a complex of proteins that include a Ca(2+) pore forming component and accessory proteins that are either required for its channel activity or regulate it under various conditions.

TL;DR: It is demonstrated that the inhibition of oxidative metabolism in T cells by ETO is independent of its effects on FAO at concentrations exceeding 5 μM, and caution should be used when employing this compound for studies in cells due to its non-specific effects on oxidative metabolism and cellular redox.

TL;DR: The findings suggest that manipulation of the noncanonical NF-κB pathway in future CAR T cell designs may provide clinical benefit, and demonstrate the necessary and nonredundant role of ncNF-κBs signaling in promoting the survival of BBζ CAR T cells, which likely underlies the engraftment persistence observed with this CAR design.

TL;DR: The results suggest that TRPA1 is likely a major target of these commonly used defensive chemicals, as a channel with cysteines at 621, 641, 665 mutated to serine responded robustly.

TL;DR: In this article, the relationship between physician assigned priority scoring (PAPS), the Medically Necessary, Time Sensitive (MeNTS) scoring system and delay to surgery was investigated.