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Benjamin Vincent
Researcher at Massachusetts Institute of Technology
Publications - 16
Citations - 764
Benjamin Vincent is an academic researcher from Massachusetts Institute of Technology. The author has contributed to research in topics: Drug resistance & Candida albicans. The author has an hindex of 11, co-authored 16 publications receiving 631 citations. Previous affiliations of Benjamin Vincent include Howard Hughes Medical Institute.
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Fitness trade-offs restrict the evolution of resistance to amphotericin B.
TL;DR: The rarity of clinical drug resistance to the antifungal amphotericin B is explained by the extreme costs that resistance mutations impose upon stress responses and virulence factors.
Fitness Trade-offs Restrict the Evolution of Resistance to Amphotericin B
TL;DR: In this article, the authors used whole genome sequencing of rare AmB-resistant clinical isolates as well as laboratory-evolved strains to identify and investigate mutations that confer AmB resistance in vitro.
Journal ArticleDOI
Inhibiting Stearoyl-CoA Desaturase Ameliorates α-Synuclein Cytotoxicity
Benjamin Vincent,Daniel F. Tardiff,Jeff S. Piotrowski,Rebecca Aron,Matthew C. Lucas,Chee Yeun Chung,Helene Bacherman,Yiqun Chen,Michelle Pires,Radha Subramaniam,Dimple B. Doshi,Heather Sadlish,Waseem K. Raja,Eric Solis,Vikram Khurana,Bertrand Le Bourdonnec,Robert H. Scannevin,Kenneth J. Rhodes +17 more
TL;DR: It is suggested that inhibition of fatty acid desaturation has potential as a therapeutic approach for the treatment of Parkinson's disease and other synucleinopathies.
Journal ArticleDOI
Nontoxic antimicrobials that evade drug resistance
Stephen Davis,Benjamin Vincent,Matthew M. Endo,Luke Whitesell,Karen Marchillo,David R. Andes,Susan Lindquist,Martin D. Burke +7 more
TL;DR: In this article, the authors show that highly selective cytocidal action and evasion of resistance are not mutually exclusive, suggesting practical routes to the discovery of less toxic, resistance-evasive therapies.
Nontoxic antimicrobials that evade drug resistance
Stephen Davis,Benjamin Vincent,Matthew M. Endo,Luke Whitesell,Karen Marchillo,David R. Andes,Susan Lindquist,Martin D. Burke +7 more
TL;DR: Surprisingly, exhaustive efforts to select for mutants resistant to these more selective compounds revealed that they are just as impervious to resistance as AmB, suggesting practical routes to the discovery of less toxic, resistance-evasive therapies.