K
Kenneth J. Rhodes
Researcher at Biogen Idec
Publications - 98
Citations - 9050
Kenneth J. Rhodes is an academic researcher from Biogen Idec. The author has contributed to research in topics: Potassium channel & Protein subunit. The author has an hindex of 39, co-authored 94 publications receiving 7982 citations. Previous affiliations of Kenneth J. Rhodes include American Cyanamid & Princeton University.
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Journal ArticleDOI
The antibody aducanumab reduces Aβ plaques in Alzheimer’s disease
Jeff Sevigny,Ping Chiao,Thierry Bussiere,Paul H. Weinreb,Leslie Williams,Marcel Maier,Robert Dunstan,Stephen Salloway,Tianle Chen,Yan Ling,John O'Gorman,Fang Qian,Mahin Arastu,Mingwei Li,Sowmya Chollate,Melanie S. Brennan,Omar Quintero-Monzon,Robert H. Scannevin,H. Moore Arnold,Thomas Engber,Kenneth J. Rhodes,James Ferrero,Yaming Hang,Alvydas Mikulskis,Jan Grimm,Christoph Hock,Roger M. Nitsch,Alfred Sandrock +27 more
TL;DR: In patients with prodromal or mild AD, one year of monthly intravenous infusions of aducanumab reduces brain Aβ in a dose- and time-dependent manner, accompanied by a slowing of clinical decline measured by Clinical Dementia Rating—Sum of Boxes and Mini Mental State Examination scores.
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Modulation of A-type potassium channels by a family of calcium sensors
An Wenqian,Mark R. Bowlby,M. Betty,Jie Cao,Huai-ping Ling,G. Mendoza,J. W. Hinson,K. I. Mattsson,Brian W. Strassle,James S. Trimmer,Kenneth J. Rhodes +10 more
TL;DR: Three Kv channel-interacting proteins (KChIPs) that bind to the cytoplasmic amino termini of Kv4 α-subunits are described that may regulate A-type currents, and hence neuronal excitability, in response to changes in intracellular calcium.
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Localization of voltage-gated ion channels in mammalian brain
TL;DR: Progress made in recent studies aimed at localizing specific ion channel subunits using in situ hybridization and immunohistochemistry are reviewed and the implications are discussed in terms of neuronal physiology and neuronal mechanisms underlying the observed patterns of expression.
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Fumarates Promote Cytoprotection of Central Nervous System Cells against Oxidative Stress via the Nuclear Factor (Erythroid-Derived 2)-Like 2 Pathway
Robert H. Scannevin,Sowmya Chollate,Mi Young Jung,Melanie N. Shackett,Hiral Patel,Pradeep Bista,Weike Zeng,Sarah Ryan,Masayuki Yamamoto,Matvey E. Lukashev,Kenneth J. Rhodes +10 more
TL;DR: DMF and MMF are cytoprotective for neurons and astrocytes against oxidative stress-induced cellular injury and loss, potentially via up-regulation of an Nrf2-dependent antioxidant response, and these data suggest DMF andMMF may function through improving mitochondrial function.
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βSubunits Promote K+ Channel Surface Expression through Effects Early in Biosynthesis
Gongyi Shi,Kensuke Nakahira,Scott M. Hammond,Kenneth J. Rhodes,Lee E. Schechter,James S. Trimmer +5 more
TL;DR: Results indicate that while some cytoplasmic K+ channel beta subunits affect the inactivation kinetics of alpha subunits, a more general, and perhaps more fundamental, role is to mediate the biosynthetic maturation and surface expression of voltage-gated K+Channel complexes.