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Benjamin W. Casterline
Researcher at University of Chicago
Publications - 5
Citations - 190
Benjamin W. Casterline is an academic researcher from University of Chicago. The author has contributed to research in topics: Bacteroides fragilis & Microbiome. The author has an hindex of 3, co-authored 5 publications receiving 139 citations.
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Journal ArticleDOI
Strain competition restricts colonization of an enteric pathogen and prevents colitis
Aaron L. Hecht,Benjamin W. Casterline,Zachary M. Earley,Young Ah Goo,David R. Goodlett,Juliane Bubeck Wardenburg +5 more
TL;DR: A novel role of type VI secretion systems in colonization resistance against a pathogen is demonstrated and this understanding of bacterial competition may be utilized to define a molecularly targeted probiotic strategy.
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The Bacteroides fragilis pathogenicity island links virulence and strain competition.
TL;DR: It is shown here that a second enterotoxigenic strain is competent to colonize, dependent on the Bacteroides fragilis pathogenicity island (BFPAI), suggesting that virulence factors may be adapted to modify the colonic niche to provide a strain-specific colonization advantage.
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A Two-Component System Regulates Bacteroides fragilis Toxin to Maintain Intestinal Homeostasis and Prevent Lethal Disease
TL;DR: It is found that Muc2-deficient mice succumb to lethal disease from ETBF colonization in a B. fragilis toxin (BFT)-dependent manner, and a toxin regulator, the two-component system RprXY, is identified, which suppresses BFT expression in vitro and in–vivo.
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Early development of the skin microbiome: therapeutic opportunities
TL;DR: How recent insight into the host and microbial factors driving development of the skin microbiome in early life offers new opportunities for therapeutic intervention is considered.