B
Bernadet T. Santema
Researcher at University of Groningen
Publications - 8
Citations - 141
Bernadet T. Santema is an academic researcher from University of Groningen. The author has contributed to research in topics: Heart failure & Atrial fibrillation. The author has an hindex of 3, co-authored 8 publications receiving 70 citations.
Papers
More filters
Journal ArticleDOI
Comparing biomarker profiles of patients with heart failure: atrial fibrillation vs. sinus rhythm and reduced vs. preserved ejection fraction
Bernadet T. Santema,Mariëlle Kloosterman,Isabelle C. Van Gelder,Ify R. Mordi,Chim C. Lang,Carolyn S.P. Lam,Stefan D. Anker,John G.F. Cleland,John G.F. Cleland,Kenneth Dickstein,Kenneth Dickstein,Gerasimos Filippatos,Pim van der Harst,Hans L. Hillege,Jozine M. ter Maaten,Marco Metra,Leong L. Ng,Leong L. Ng,Piotr Ponikowski,Nilesh J. Samani,Nilesh J. Samani,Dirk J. van Veldhuisen,Aeilko H. Zwinderman,Faiez Zannad,Kevin Damman,Peter van der Meer,Michiel Rienstra,Adriaan A. Voors +27 more
TL;DR: In patients with HFrEF, the presence of AF was associated with a homogeneously elevated cardiovascular risk marker profile, suggesting differences in underlying pathophysiological mechanisms of AF in these HF phenotypes, compared with patients with HFpEF.
Journal ArticleDOI
Sex-Specific Differences in Heart Failure: Pathophysiology, Risk Factors, Management, and Outcomes.
Kristen Sullivan,Barbara S. Doumouras,Bernadet T. Santema,Mary Norine Walsh,Pamela S. Douglas,Adriaan A. Voors,Harriette G.C. Van Spall +6 more
TL;DR: In this paper, a review outlines the sex-specific differences in HF phenotype and treatment response, and highlights disparities in services and gaps in knowledge that merit further investigation, highlighting the need to include female patients proportionate to the sex specific distribution of disease.
Journal ArticleDOI
The influence of atrial fibrillation on the levels of NT-proBNP versus GDF-15 in patients with heart failure
Bernadet T. Santema,Michelle Chan,Jasper Tromp,Martin M Dokter,Haye H. van der Wal,Johanna E. Emmens,Janny Takens,Nilesh J. Samani,Nilesh J. Samani,Leong L. Ng,Leong L. Ng,Chim C. Lang,Peter van der Meer,Jozine M. ter Maaten,Kevin Damman,Kenneth Dickstein,Kenneth Dickstein,John G.F. Cleland,John G.F. Cleland,Faiez Zannad,Stefan D. Anker,Marco Metra,Pim van der Harst,Rudolf A. de Boer,Dirk J. van Veldhuisen,Michiel Rienstra,Carolyn S.P. Lam,Adriaan A. Voors +27 more
TL;DR: In patients with HF, NT-proBNP is significantly influenced by underlying AF at time of measurement and not by previous episodes of AF, whereas the levels of GDF-15 are not influenced by the presence of AF.
Journal ArticleDOI
Quality of life in men and women with heart failure: association with outcome, and comparison between the Kansas City Cardiomyopathy Questionnaire and the EuroQol 5 dimensions questionnaire.
Alice Ravera,Alice Ravera,Bernadet T. Santema,Iziah E Sama,Sven Meyer,Carlo Lombardi,Valentina Carubelli,João Pedro Ferreira,Chim C. Lang,Kenneth Dickstein,Stefan D. Anker,Nilesh J. Samani,Faiez Zannad,Dirk J. van Veldhuisen,John R. Teerlink,Marco Metra,Adriaan A. Voors +16 more
TL;DR: In this article, the authors analyse quality of life measures derived from two questionnaires widely used in clinical trials, the Kansas City Cardiomyopathy Questionnaire (KCCQ) and the EuroQoL 5 dimensions (EQ-5D), and compare their prognostic value in men and women with heart failure and reduced ejection fraction (HFrEF).
Journal ArticleDOI
Differences in biomarkers and molecular pathways according to age for patients with HFrEF.
João Pedro Ferreira,Wouter Ouwerkerk,Bernadet T. Santema,Dirk J. van Veldhuisen,Chim C. Lang,Leong L. Ng,Stefan D. Anker,Kenneth Dickstein,Marco Metra,John G.F. Cleland,Samani J Nilesh,Gerasimos Filippatos,Joseph-Pierre Aboumsallem,Rudolf A. de Boer,Sylwia M. Figarska,Iziah E Sama,Adriaan A. Voors,Faiez Zannad +17 more
TL;DR: Using a large set of circulating proteins, elderly patients had higher concentrations of proteins associated with tumor cell regulation, extra-cellular matrix organization, and inflammatory processes, whereas pathways that may point to cell proliferation and tumorigenesis were down-regulated.