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Bernadette Jones
Researcher at University of Newcastle
Publications - 12
Citations - 1262
Bernadette Jones is an academic researcher from University of Newcastle. The author has contributed to research in topics: COPD & Inflammation. The author has an hindex of 8, co-authored 12 publications receiving 914 citations. Previous affiliations of Bernadette Jones include University of Technology, Sydney.
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Journal ArticleDOI
The adaptor ASC has extracellular and 'prionoid' activities that propagate inflammation
Bernardo S. Franklin,Lukas Bossaller,Dominic De Nardo,Jacqueline M Ratter,Andrea Stutz,Gudrun Engels,Christoph Brenker,Mark Nordhoff,Sandra R Mirandola,Ashraf Al-Amoudi,Matthew Mangan,Sebastian Zimmer,Brian G. Monks,Martin Fricke,Reinhold E. Schmidt,Terje Espevik,Bernadette Jones,Andrew G. Jarnicki,Philip M. Hansbro,Patricia Busto,Ann Marshak-Rothstein,Simone Hornemann,Adriano Aguzzi,Wolfgang Kastenmüller,Eicke Latz +24 more
TL;DR: It is found that after pyroptosis, ASC specks accumulated in the extracellular space, where they promoted further maturation of IL-1β, and a previously unknown form of cell-to-cell communication is revealed.
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MicroRNA-21 drives severe, steroid-insensitive experimental asthma by amplifying phosphoinositide 3-kinase–mediated suppression of histone deacetylase 2
Richard Kim,Jay C. Horvat,James W. Pinkerton,Malcolm R. Starkey,Ama Tawiah Essilfie,Jemma R. Mayall,Prema M. Nair,Nicole G. Hansbro,Bernadette Jones,Tatt Jhong Haw,Krishna P. Sunkara,Thi Hiep Nguyen,Andrew G. Jarnicki,Simon Keely,Joerg Mattes,Ian M. Adcock,Paul S. Foster,Philip M. Hansbro +17 more
TL;DR: A previously unrecognized role for an miR‐21/PI3K/HDAC2 axis in SSIAAD is identified and highlighted as a novel therapeutic target for the treatment of this form of asthma.
Journal ArticleDOI
Animal models of COPD: What do they tell us?
Bernadette Jones,Chantal Donovan,Gang Liu,H. Gomez,Vrushali Chimankar,Celeste L. Harrison,Cornelis Wiegman,Ian M. Adcock,Darryl A. Knight,Jeremy A. Hirota,Philip M. Hansbro +10 more
TL;DR: The different established animal models of COPD and the various aspects of disease pathophysiology that have been successfully recapitulated in these models including chronic lung inflammation, airway remodelling, emphysema and impaired lung function are reviewed.
Journal ArticleDOI
Chronic cigarette smoke exposure induces systemic hypoxia that drives intestinal dysfunction
Michael Fricker,Bridie J. Goggins,Sean W. Mateer,Bernadette Jones,Richard Kim,Shaan L. Gellatly,Andrew G. Jarnicki,Nick Powell,Brian G. Oliver,Graham L. Radford-Smith,Nicholas J. Talley,Marjorie M. Walker,Simon Keely,Philip M. Hansbro +13 more
TL;DR: There is strong evidence that chronic CS exposure and, for the first time, associated impaired gas exchange cause systemic and intestinal ischemia, driving angiogenesis and GIT epithelial barrier dysfunction, resulting in increased risk and severity of CD.
Journal ArticleDOI
Necroptosis Signaling Promotes Inflammation, Airway Remodeling, and Emphysema in Chronic Obstructive Pulmonary Disease.
Zhe Lu,Hannelore Van Eeckhoutte,Gang Liu,Gang Liu,Prema M. Nair,Bernadette Jones,Caitlin M Gillis,Caitlin M Gillis,B Christina Nalkurthi,Fien M. Verhamme,Tamariche Buyle-Huybrecht,Peter Vandenabeele,Tom Vanden Berghe,Tom Vanden Berghe,Guy Brusselle,Jay C. Horvat,James M. Murphy,James M. Murphy,Peter A. B. Wark,Ken R. Bracke,Michael Fricker,Philip M. Hansbro,Philip M. Hansbro +22 more
TL;DR: In this article, the role of RIPK3 and MLKL in chronic obstructive pulmonary disease (COPD) pathogenesis was investigated in mice with and without COPD.