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Darryl A. Knight
Researcher at University of Newcastle
Publications - 225
Citations - 12444
Darryl A. Knight is an academic researcher from University of Newcastle. The author has contributed to research in topics: Respiratory epithelium & Idiopathic pulmonary fibrosis. The author has an hindex of 60, co-authored 218 publications receiving 10630 citations. Previous affiliations of Darryl A. Knight include University of British Columbia & Health Canada.
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Journal ArticleDOI
The airway epithelium: Structural and functional properties in health and disease
TL;DR: Analysis of the ontogeny of the disease in children and use of gene array technology should provide some important answers to allow a better understanding of the critical role that the epithelium plays under normal conditions and in diseases such as asthma.
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Inhibition of Wnt/β-catenin/CREB binding protein (CBP) signaling reverses pulmonary fibrosis
William R. Henderson,Emil Y. Chi,Xin Ye,Cu Nguyen,Ying Tzang Tien,Beiyun Zhou,Zea Borok,Darryl A. Knight,Michael Kahn +8 more
TL;DR: It is reported here that ICG-001 significantly inhibits β-catenin signaling and attenuates bleomycin-induced lung fibrosis in mice, while concurrently preserving the epithelium.
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Airway smooth muscle dynamics: A common pathway of airway obstruction in asthma
Steven S. An,Tony R. Bai,Jason H. T. Bates,Judith L. Black,Robert H. Brown,Vito Brusasco,Pasquale Chitano,Linhong Deng,Linhong Deng,Maria Dowell,David H. Eidelman,Ben Fabry,Nigel J. Fairbank,Lincoln E. Ford,Jeffrey J. Fredberg,William T. Gerthoffer,S. H. Gilbert,Reinoud Gosens,S. J. Gunst,Andrew J. Halayko,R. H. Ingram,Charles G. Irvin,Alan L. James,Luke J. Janssen,Gregory G. King,Darryl A. Knight,Anne-Marie Lauzon,O. J. Lakser,Mara S. Ludwig,Kenneth R. Lutchen,Geoffrey N. Maksym,James G. Martin,Thais Mauad,Brent E. McParland,Srboljub M. Mijailovich,Howard W. Mitchell,Richard W. Mitchell,Wayne Mitzner,Thomas M. Murphy,Peter D. Paré,Riccardo Pellegrino,Michael J. Sanderson,R. Robert Schellenberg,Chun Y. Seow,Paulo Sérgio Panse Silveira,Paul G. Smith,Julian Solway,Newman L. Stephens,Peter J. Sterk,Alastair G. Stewart,Dale D. Tang,Robert S. Tepper,Thai Tran,Lu Wang +53 more
TL;DR: A central role for airway smooth muscle in the pathogenesis of airway hyperresponsiveness in asthma is explored and an attempt is made to address a fundamental abnormality of asthma, that of exaggerated airway narrowing due to excessive shortening of ASM.
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Activation of Protease-Activated Receptor (PAR)-1, PAR-2, and PAR-4 Stimulates IL-6, IL-8, and Prostaglandin E2 Release from Human Respiratory Epithelial Cells
Nithiananthan Asokananthan,Peter T. Graham,Joshua Fink,Darryl A. Knight,Anthony J. Bakker,Andrew S. McWilliam,Philip J. Thompson,Geoffrey A. Stewart +7 more
TL;DR: Data suggest an important role for PAR in the modulation of inflammation in the lung and suggests differential G protein coupling.
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Induction of Epithelial–Mesenchymal Transition in Primary Airway Epithelial Cells from Patients with Asthma by Transforming Growth Factor-β1
Tillie-Louise Hackett,Stephanie M. Warner,Dorota Stefanowicz,Furquan Shaheen,Dmitri V. Pechkovsky,Lynne Murray,Rochelle L. Argentieri,Anthony Kicic,Stephen M. Stick,Tony R. Bai,Darryl A. Knight +10 more
TL;DR: The hypothesis that epithelial repair in asthmatic airways is dysregulated is supported, as TGF-beta1 induces EMT in a Smad3-dependent manner in primary AECs.