B
Bernard D. Davis
Researcher at Harvard University
Publications - 178
Citations - 11944
Bernard D. Davis is an academic researcher from Harvard University. The author has contributed to research in topics: Ribosome & Polysome. The author has an hindex of 54, co-authored 178 publications receiving 11761 citations. Previous affiliations of Bernard D. Davis include Rockefeller University & United States Public Health Service.
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Bacillus licheniformis penicillinase: cleavages and attachment of lipid during cotranslational secretion.
TL;DR: The penicillinase of Bacillus licheniformis is shown to be secreted cotranslationally, and after extracellular labeling of cells, followed by completion of the growing chains on polysomes in vitro, labeled peniillinase could be immunoprecipitated.
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Extracellular labeling of growing secreted polypeptide chains in Bacillus subtilis with diazoiodosulfanilic acid.
TL;DR: The reagent used for extracellular labeling, [1252]diazoiodosulfanilic acid, yielded severalfold more specific labeling of the nascent chains than was obtained earlier with another nonpenetrating reagent.
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Rapid exchange of subunits between free ribosomes in extracts of Escherichia coli.
TL;DR: It is found that the dissociation of free heavy ribosome as they advance in a sucrose gradient causes a serious artefact in the demonstration of hybrid ribosomes, and the previously reported exchange thus does not provide evidence for formation of free subunits during runoff.
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Triphasic concentration effects of gentamicin on activity and misreading in protein synthesis.
Phang C. Tai,Bernard D. Davis +1 more
TL;DR: It is concluded that binding of gentamicin to its first site causes inhibition but little misreading; binding to additional site(s) partly reverses the inhibition by first-site binding and markedly stimulates misreading, and the misreading appears to favor "readthrough" of termination codons.
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Selective Inhibition of Initiating Ribosomes by Spectinomycin
TL;DR: Cyclic reinitiation by the sensitive ribosomes, each blocking an initiation site for an average of 10-15 min, can explain (just as with streptomycin) the dominance of sensitivity over resistance.