Bernd Kaspers

TL;DR: Sequence homology and structural features indicate that this protein is the chicken homolog of mammalian interleukin-1beta (ChIL-1 beta), and northern blot analysis showed that ChIL- 1 beta RNA is quickly induced in blood monocyte-derived macrophages reaching maximal levels within one hour after onset of LPS treatment.

TL;DR: From the initial data on the biochemical properties of these molecules, a picture is emerging that shows that avian and mammalian cytokines may perform similar tasks, although their primary structures in most cases are remarkably different.

TL;DR: Two major, phenotypically and functionally distinct IEL subpopulations are defined, and imply an important role of NK cells in the mucosal immune system.

TL;DR: Bacterially expressed chicken IL-6 carrying a histidine tag in place of the signal peptide was biologically active: it induced proliferation of the IL- 6-dependent murine hybridoma cell line 7TD1, demonstrating that recombinant ChIL-6 from eukaryotic cells is also active.

TL;DR: An efficient way to target genes of interest in the chicken genome and create knockout chickens is described, targeted the immunoglobulin heavy chain gene, leading to loss of antibody production and a block in B-cell development.