Bernhard Rambeck

TL;DR: Following guidelines for TDM in psychiatry will help to improve the outcomes of psychopharmacotherapy of many patients especially in case of pharmacokinetic problems, and one should never forget that TDM is an interdisciplinary task that sometimes requires the respectful discussion of apparently discrepant data.

TL;DR: Following guidelines for TDM in psychiatry will help to improve the outcomes of psychopharmacotherapy of many patients especially in case of pharmacokinetic problems, and one should never forget that TDM is an interdisciplinary task that sometimes requires the respectful discussion of apparently discrepant data.

TL;DR: Observations indicate that the interaction of carbamazepine and lamotrigine may be primarily pharmacodynamic rather than pharmacokinetic, and the incidence of adverse effects is low and that unwanted effects are reversible.

TL;DR: In general, daily fluctuations of MHD concentration are relatively slight, smaller than would be expected from the elimination half-life of M HD, however, relatively high fluctuations can be observed in individual patients.

TL;DR: Concentrations of AEDs in the extracellular space of human neocortical tissue were measured by using intraoperative microdialysis (IOMD) in those parts of the brain that had to be removed for therapeutic reasons.