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Bert Pronk
Researcher at Durham University
Publications - 2
Citations - 163
Bert Pronk is an academic researcher from Durham University. The author has contributed to research in topics: Hsp90 & Prodrug. The author has an hindex of 1, co-authored 2 publications receiving 148 citations.
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Discovery of novel 2-aminobenzamide inhibitors of heat shock protein 90 as potent, selective and orally active antitumor agents.
Kenneth He Huang,James Marvin Veal,Patrick Fadden,John W. Rice,Jeron Eaves,Jon-Paul Strachan,Amy F. Barabasz,Briana Foley,Barta Thomas E,Wei Ma,Melanie Silinski,Mei Hu,Jeffrey M. Partridge,Anisa Scott,Laura G. Dubois,Tiffany Freed,Paul M. Steed,Andy J. Ommen,Emilie D. Smith,Philip F. Hughes,Angela R. Woodward,Hanson Gunnar J,W. Stephen Mccall,Christopher John Markworth,Lindsay Hinkley,Matthew Jenks,Geng Lifeng,Meredith Lewis,James C. Otto,Bert Pronk,Katleen Verleysen,Steven E. Hall +31 more
TL;DR: A novel class of heat shock protein 90 (Hsp90) inhibitors was developed from an unbiased screen to identify protein targets for a diverse compound library, and optimized analogues exhibited nanomolar antiproliferative activity across multiple cancer cell lines.
Journal Article
A novel, orally active, small molecule Hsp90 inhibitor.
Patrick Fadden,Amy F. Barabasz,Tom Barta,Jeron Eaves,Briana Foley,Geng Lifeng,Steven E. Hall,Hanson Gunnar J,He Huang,James C. Otto,Bert Pronk,John R. Rice,James Marvin Veal +12 more
TL;DR: In vitro and in vivo evidence, presented herein, demonstrate that SNX-5542 acts as a highly selective Hsp90 inhibitor with activity and efficacy equivalent to or better than published HSp90 inhibitors.