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Beryl Hartley-Asp
Researcher at Lund University
Publications - 28
Citations - 1033
Beryl Hartley-Asp is an academic researcher from Lund University. The author has contributed to research in topics: Estramustine & Estromustine. The author has an hindex of 16, co-authored 28 publications receiving 1029 citations.
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The influence of caffeine on the mitomycin C-induced chromosome aberration frequency in normal human and xeroderma pigmentosum cells.
TL;DR: The clastogenic effect of mitomycin C (MC) was determined in two normal fibroblast cell lines and two xeroderma pigmentosum (XP) cell lines, a variant and a group A excision-deficient line, with a distinctly higher sensitivity to caffeine than the classical XP or the normal human cell line.
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Identification by C-banding of two human prostate tumour cell lines, 1013L and DU 145.
TL;DR: Karyotype analysis using G‐banding revealed that DU 145 had retained several of its original markers, and demonstrated multiple marker chromosomes in 1013L.
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Distribution and metabolism of estramustine in HeLa cells and the human prostatic tumour cell line 1013L.
TL;DR: The results extend the knowledge concerning EM and demonstrate that the cell line 1013L is a relevant model system for studying drugs active against human prostatic tumours.
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Studies on the mechanism of action of LS 1727, a nitrosocarbamate of 19-nortestosterone.
TL;DR: In vivo studies with specific alkylating agent-sensitive, or antimetabolite-sensitive tumours showed no antitumour activity although significant inhibition of Ehrlich ascites tumour cell growth was observed at high doses, suggesting a possible antimetabolic mode of action.
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The effect of estramustine, nor-nitrogen mustard and tauromustine on macromolecular labelling in the human prostatic tumour cell line 1013L.
TL;DR: The influence on macromolecular synthesis in the human prostatic tumour cell line 1013L was investigated and an inhibition of overall RNA synthesis was predominant, indicating disturbances in either RNA processing or RNA transport.