B
Beth S. Ruben
Researcher at University of California, San Francisco
Publications - 52
Citations - 2232
Beth S. Ruben is an academic researcher from University of California, San Francisco. The author has contributed to research in topics: Nail (anatomy) & Nail plate. The author has an hindex of 16, co-authored 52 publications receiving 1857 citations. Previous affiliations of Beth S. Ruben include University of California & Palo Alto Medical Foundation.
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Journal ArticleDOI
The Genetic Evolution of Melanoma from Precursor Lesions
A. Hunter Shain,Iwei Yeh,Ivanka Kovalyshyn,Aravindhan Sriharan,Eric Talevich,Alexander Gagnon,Reinhard Dummer,Jeffrey P. North,Laura B. Pincus,Beth S. Ruben,William Rickaby,Corrado D’Arrigo,Alistair Robson,Boris C. Bastian +13 more
TL;DR: The succession of genetic alterations during melanoma progression was defined, showing distinct evolutionary trajectories for different melanoma subtypes, and an intermediate category of melanocytic neoplasia was identified, characterized by the presence of more than one pathogenic genetic alteration and distinctive histopathological features.
Journal ArticleDOI
Acrodermatitis enteropathica and an overview of zinc metabolism
Emanual Michael Maverakis,Maxwell A Fung,Peter Lynch,Michelle Draznin,Daniel J. Michael,Beth S. Ruben,Nasim Fazel +6 more
TL;DR: In this paper, the authors provide an overview of zinc metabolism and a description of inherited and acquired zinc deficiency, which is made by way of clinical presentation together with histopathology and laboratory tests.
Journal Article
Classification, clinical manifestations, and immunopathological mechanisms of the epithelial variant of paraneoplastic autoimmune multiorgan syndrome: a reappraisal of paraneoplastic pemphigus.
Vu Thuong Nguyen,Assane Ndoye,Karl D. Bassler,Leonard D. Shultz,Molly C. Shields,Beth S. Ruben,Robert J. Webber,Mark R. Pittelkow,Peter Lynch,Sergei A. Grando +9 more
TL;DR: The more encompassing term "paraneoplastic autoimmune multiorgan syndrome," or PAMS, is suggested to be applied to classify the diverse mucocutaneous and respiratory presentations of PNP and characterize the effectors of humoral and cellular autoimmunity mediating epithelial tissue damage.
Journal ArticleDOI
Genomic and Transcriptomic Analysis Reveals Incremental Disruption of Key Signaling Pathways during Melanoma Evolution.
A. Hunter Shain,Nancy M. Joseph,Richard Yu,Jamal Benhamida,Shanshan Liu,Tarl W. Prow,Beth S. Ruben,Beth S. Ruben,Jeffrey P. North,Laura B. Pincus,Iwei Yeh,Robert L. Judson,Boris C. Bastian +12 more
TL;DR: Genomic and transcriptomic changes that accompany the evolution of melanoma from pre-malignant lesions are elucidated by sequencing DNA and RNA from primary melanomas and their adjacent precursors, as well as matched primary tumors and regional metastases.
Journal ArticleDOI
Bi-allelic Loss of CDKN2A Initiates Melanoma Invasion via BRN2 Activation.
Hanlin Zeng,Aparna Jorapur,A. Hunter Shain,Ursula E. Lang,Rodrigo Torres,Yuntian Zhang,Andrew S. McNeal,Thomas Botton,Jue Lin,Matthew Donne,Ingmar N. Bastian,Richard Yu,Jeffrey P. North,Laura B. Pincus,Beth S. Ruben,Beth S. Ruben,Nancy M. Joseph,Iwei Yeh,Boris C. Bastian,Robert L. Judson +19 more
TL;DR: A mechanism by which CDKN2A suppresses the initiation of melanoma invasion through inhibition of BRN2 is demonstrated, which is downstream of CDKN1 and directly regulated by E2F1.