L
Laura B. Pincus
Researcher at University of California, San Francisco
Publications - 65
Citations - 2484
Laura B. Pincus is an academic researcher from University of California, San Francisco. The author has contributed to research in topics: Lymphoma & Mycosis fungoides. The author has an hindex of 21, co-authored 62 publications receiving 1949 citations. Previous affiliations of Laura B. Pincus include Medical Research Council & Leiden University.
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Journal ArticleDOI
The Genetic Evolution of Melanoma from Precursor Lesions
A. Hunter Shain,Iwei Yeh,Ivanka Kovalyshyn,Aravindhan Sriharan,Eric Talevich,Alexander Gagnon,Reinhard Dummer,Jeffrey P. North,Laura B. Pincus,Beth S. Ruben,William Rickaby,Corrado D’Arrigo,Alistair Robson,Boris C. Bastian +13 more
TL;DR: The succession of genetic alterations during melanoma progression was defined, showing distinct evolutionary trajectories for different melanoma subtypes, and an intermediate category of melanocytic neoplasia was identified, characterized by the presence of more than one pathogenic genetic alteration and distinctive histopathological features.
Journal ArticleDOI
Genomic and Transcriptomic Analysis Reveals Incremental Disruption of Key Signaling Pathways during Melanoma Evolution.
A. Hunter Shain,Nancy M. Joseph,Richard Yu,Jamal Benhamida,Shanshan Liu,Tarl W. Prow,Beth S. Ruben,Beth S. Ruben,Jeffrey P. North,Laura B. Pincus,Iwei Yeh,Robert L. Judson,Boris C. Bastian +12 more
TL;DR: Genomic and transcriptomic changes that accompany the evolution of melanoma from pre-malignant lesions are elucidated by sequencing DNA and RNA from primary melanomas and their adjacent precursors, as well as matched primary tumors and regional metastases.
Journal ArticleDOI
Cutaneous γδ T-cell lymphomas: a spectrum of presentations with overlap with other cytotoxic lymphomas.
Joan Guitart,Dennis D. Weisenburger,Antonio Subtil,Ellen Kim,Gary S. Wood,Madeleine Duvic,Elise A. Olsen,Jacqueline M. Junkins-Hopkins,Steve Rosen,Uma Sundram,Doina Ivan,M. Angelica Selim,Laura B. Pincus,Janyana M.D. Deonizio,Mary J. Kwasny,Youn H. Kim +15 more
TL;DR: This is the largest study to date of cutaneous T-cell lymphomas and demonstrates a variety of clinical and pathologic presentations with a predictable poor outcome.
Journal ArticleDOI
Subcutaneous Panniculitis-Like T-Cell Lymphoma With Overlapping Clinicopathologic Features of Lupus Erythematosus: Coexistence of 2 Entities?
Laura B. Pincus,Philip E. LeBoit,Timothy H. McCalmont,Roberto Ricci,Carlo Buzio,Lindy P. Fox,Fergus Oliver,Lorenzo Cerroni +7 more
TL;DR: 5 patients with subcutaneous panniculitis-like T-cell lymphoma (SPTCL) who were unusual, in that they also exhibited features of lupus erythematosus (LE), are observed and it is suspected that these patients may suffer from both diseases concomitantly.
Journal ArticleDOI
Bi-allelic Loss of CDKN2A Initiates Melanoma Invasion via BRN2 Activation.
Hanlin Zeng,Aparna Jorapur,A. Hunter Shain,Ursula E. Lang,Rodrigo Torres,Yuntian Zhang,Andrew S. McNeal,Thomas Botton,Jue Lin,Matthew Donne,Ingmar N. Bastian,Richard Yu,Jeffrey P. North,Laura B. Pincus,Beth S. Ruben,Beth S. Ruben,Nancy M. Joseph,Iwei Yeh,Boris C. Bastian,Robert L. Judson +19 more
TL;DR: A mechanism by which CDKN2A suppresses the initiation of melanoma invasion through inhibition of BRN2 is demonstrated, which is downstream of CDKN1 and directly regulated by E2F1.