B
Bianca Busch
Researcher at Martin Luther University of Halle-Wittenberg
Publications - 7
Citations - 340
Bianca Busch is an academic researcher from Martin Luther University of Halle-Wittenberg. The author has contributed to research in topics: microRNA & Gene expression. The author has an hindex of 5, co-authored 7 publications receiving 208 citations.
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Journal ArticleDOI
IGF2BP1 enhances an aggressive tumor cell phenotype by impairing miRNA-directed downregulation of oncogenic factors.
Simon Müller,Nadine Bley,Markus Glaß,Bianca Busch,Vanessa Rousseau,Danny Misiak,Tommy Fuchs,Marcell Lederer,Stefan Hüttelmaier +8 more
TL;DR: Findings indicate that IGF2BP1 enhances an aggressive tumor cell phenotype by antagonizing miRNA-impaired gene expression.
Journal ArticleDOI
The oncogenic triangle of HMGA2, LIN28B and IGF2BP1 antagonizes tumor-suppressive actions of the let-7 family.
Bianca Busch,Nadine Bley,Simon Müller,Markus Glaß,Danny Misiak,Marcell Lederer,Martina Vetter,Hans-Georg Strauß,Christoph Thomssen,Stefan Hüttelmaier +9 more
TL;DR: The targeting of the HMGA2-LIN28B-IGF2BP1 triangle is suggested as a promising strategy in cancer treatment because the expression of the triangle factors is inversely correlated with let-7 levels and promoted by LIN28B impairingLet-7 biogenesis.
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The oncofetal RNA-binding protein IGF2BP1 is a druggable, post-transcriptional super-enhancer of E2F-driven gene expression in cancer.
Simon Müller,Nadine Bley,Bianca Busch,Markus Glaß,Marcell Lederer,Claudia Misiak,Tommy Fuchs,Alice Wedler,Jacob Haase,Jean B. Bertoldo,Patrick Michl,Stefan Hüttelmaier +11 more
TL;DR: It is revealed that IGF2BP1 is a post-transcriptional enhancer of the E2F-driven hallmark in solid cancers, and the small molecule BTYNB disrupts this enhancer function by impairing IGF2 BP1-RNA association.
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Rapid identification of regulatory microRNAs by miTRAP (miRNA trapping by RNA in vitro affinity purification)
TL;DR: In this paper, the authors describe miTRAP (miRNA trapping by RNA in vitro affinity purification), an advanced protocol of previously reported MS2-tethering approaches that allows the rapid identification of miRNAs targeting an in vitro transcribed RNA in cell lysates.
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Activated mineralocorticoid receptor regulates micro-RNA-29b in vascular smooth muscle cells
Maria Bretschneider,Bianca Busch,Daniel Mueller,Alexander Nolze,Barbara Schreier,Michael Gekle,Claudia Grossmann +6 more
TL;DR: The findings provide novel insights into the molecular mechanism of aldosterone‐mediated vascular pathogenesis by identifying miR‐29b as a pathophysiologic relevant target of activated MR in VSMCs and by highlighting the importance of miR processing for miR regulation.