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Showing papers by "Bing Zhang published in 1998"

Journal Article•DOI•
Synaptic Vesicle Size and Number Are Regulated by a Clathrin Adaptor Protein Required for Endocytosis

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Bing Zhang1, Bing Zhang2, Young Ho Koh3, Robert B. Beckstead2, Vivian Budnik3, Barry Ganetzky1, Hugo J. Bellen2 •
University of Wisconsin-Madison1, Baylor College of Medicine2, University of Massachusetts Amherst3
01 Dec 1998-Neuron
TL;DR: It is shown that a mutation that eliminates an AP180 homolog (LAP) in Drosophila severely impairs the efficiency of synaptic vesicle endocytosis and alters the normal localization of clathrin in nerve terminals.

430 citations

Journal Article•DOI•
skittles, a Drosophila Phosphatidylinositol 4-Phosphate 5-Kinase, Is Required for Cell Viability, Germline Development and Bristle Morphology, But Not for Neurotransmitter Release

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Bassem A. Hassan1, Sergei N. Prokopenko1, Sebastian Breuer2, Bing Zhang1, Achim Paululat2, Hugo J. Bellen1 •
Baylor College of Medicine1, University of Marburg2
01 Dec 1998-Genetics
TL;DR: Analysis of cloned and generated mutations in a Drosophila PIP5K type I (skittles) indicates that skittles is required for cell viability, germline development, and the proper structural development of sensory bristles.
Abstract: The phosphatidylinositol pathway is implicated in the regulation of numerous cellular functions and responses to extracellular signals. An important branching point in the pathway is the phosphorylation of phosphatidylinositol 4-phosphate by the phosphatidylinositol 4-phosphate 5-kinase (PIP5K) to generate the second messenger phosphatidylinositol 4,5-bis-phosphate (PIP2). PIP5K and PIP2 have been implicated in signal transduction, cytoskeletal regulation, DNA synthesis, and vesicular trafficking. We have cloned and generated mutations in a Drosophila PIP5K type I (skittles). Our analysis indicates that skittles is required for cell viability, germline development, and the proper structural development of sensory bristles. Surprisingly, we found no evidence for PIP5KI involvement in neural secretion.

80 citations