B
Birgit Hirsch-Hoffmann
Publications - 2
Citations - 352
Birgit Hirsch-Hoffmann is an academic researcher. The author has contributed to research in topics: Angiotensin II & Angiotensin II receptor type 1. The author has an hindex of 2, co-authored 2 publications receiving 315 citations.
Papers
More filters
Journal ArticleDOI
Myeloperoxidase acts as a profibrotic mediator of atrial fibrillation.
Volker Rudolph,René Andrié,Tanja K. Rudolph,Kai Friedrichs,Anna Klinke,Birgit Hirsch-Hoffmann,Alexander P. Schwoerer,Denise Lau,Xiaoming Fu,Karin Klingel,Karsten Sydow,Michael Didié,Michael Didié,Anika Seniuk,Eike Christin Von Leitner,Katalin Szoecs,Jan W. Schrickel,Hendrik Treede,Ulrich Wenzel,Thorsten Lewalter,Georg Nickenig,Wolfram-Hubertus Zimmermann,Wolfram-Hubertus Zimmermann,Thomas Meinertz,Rainer H. Böger,Hermann Reichenspurner,Bruce A. Freeman,Thomas Eschenhagen,Heimo Ehmke,Stanley L. Hazen,Stephan Willems,Stephan Baldus +31 more
TL;DR: Experimental and clinical evidence for the mechanistic involvement of myeloperoxidase (MPO), a heme enzyme abundantly expressed by neutrophils, in the pathophysiology of atrial fibrillation is provided.
Journal ArticleDOI
Angiotensin II type 2 receptor deficiency aggravates renal injury and reduces survival in chronic kidney disease in mice
Ralf A. Benndorf,Christian Krebs,Birgit Hirsch-Hoffmann,Edzard Schwedhelm,Gabriele Cieslar,Robin Schmidt-Haupt,Oliver M. Steinmetz,Catherine Meyer-Schwesinger,Friedrich Thaiss,Munif Haddad,Susanne Fehr,Andreas Heilmann,Udo Helmchen,Lutz Hein,Heimo Ehmke,Rolf A.K. Stahl,Rainer H. Böger,Ulrich Wenzel +17 more
TL;DR: Renal injury caused a greater impairment of renal function, glomerular injury, albuminuria, and mortality in the knockout mice than in the wild-type mice, and activation of the AT2 receptor will have therapeutic benefit in chronic kidney disease will require further study.