J
Jan W. Schrickel
Researcher at University Hospital Bonn
Publications - 109
Citations - 3056
Jan W. Schrickel is an academic researcher from University Hospital Bonn. The author has contributed to research in topics: Atrial fibrillation & Catheter ablation. The author has an hindex of 28, co-authored 104 publications receiving 2636 citations. Previous affiliations of Jan W. Schrickel include University of Bonn.
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Journal ArticleDOI
Engraftment of connexin 43-expressing cells prevents post-infarct arrhythmia
Wilhelm Roell,Thorsten Lewalter,Philipp Sasse,Yvonne N. Tallini,Bum-Rak Choi,Martin Breitbach,Robert Doran,Ulrich M. Becher,Seong-min Hwang,Toktam Bostani,Julia von Maltzahn,Andreas Hofmann,Shaun Reining,Britta Eiberger,Bethann Gabris,Alexander Pfeifer,Armin Welz,Klaus Willecke,Guy Salama,Jan W. Schrickel,Michael I. Kotlikoff,Bernd K. Fleischmann +21 more
TL;DR: Engraftment of Cx43-expressing myocytes has the potential to reduce life-threatening post-infarct arrhythmias through the augmentation of intercellular coupling, suggesting autologous strategies for cardiac cell-based therapy.
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Myeloperoxidase acts as a profibrotic mediator of atrial fibrillation.
Volker Rudolph,René Andrié,Tanja K. Rudolph,Kai Friedrichs,Anna Klinke,Birgit Hirsch-Hoffmann,Alexander P. Schwoerer,Denise Lau,Xiaoming Fu,Karin Klingel,Karsten Sydow,Michael Didié,Michael Didié,Anika Seniuk,Eike Christin Von Leitner,Katalin Szoecs,Jan W. Schrickel,Hendrik Treede,Ulrich Wenzel,Thorsten Lewalter,Georg Nickenig,Wolfram-Hubertus Zimmermann,Wolfram-Hubertus Zimmermann,Thomas Meinertz,Rainer H. Böger,Hermann Reichenspurner,Bruce A. Freeman,Thomas Eschenhagen,Heimo Ehmke,Stanley L. Hazen,Stephan Willems,Stephan Baldus +31 more
TL;DR: Experimental and clinical evidence for the mechanistic involvement of myeloperoxidase (MPO), a heme enzyme abundantly expressed by neutrophils, in the pathophysiology of atrial fibrillation is provided.
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The conditional connexin43G138R mouse mutant represents a new model of hereditary oculodentodigital dysplasia in humans
Radoslaw Dobrowolski,Philipp Sasse,Jan W. Schrickel,Marcus Watkins,Jung-Sun Kim,Mindaugas Rackauskas,Clemens Troatz,Alexander Ghanem,Klaus Tiemann,Joachim Degen,Feliksas F. Bukauskas,Roberto Civitelli,Thorsten Lewalter,Bernd K. Fleischmann,Klaus Willecke +14 more
TL;DR: The results suggest that the increased activity of ATP-releasing channels in Cx43G138R mutated cardiomyocytes may further reduce the already decreased gap junctional communication and thus aggravate arrhythmogenesis in the mouse mutant.
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Comparison of cryoballoon and radiofrequency ablation of pulmonary veins in 40 patients with paroxysmal atrial fibrillation: a case-control study.
Markus Linhart,Barbara Bellmann,Erica Mittmann-Braun,Jan W. Schrickel,Alexander Bitzen,René Andrié,Alexander Yang,Georg Nickenig,Lars Lickfett,Thorsten Lewalter +9 more
TL;DR: ABlation of pulmonary veins is an established therapeutic option for patients with symptomatic drug‐refractory paroxysmal atrial fibrillation and cryothermal energy applied with a cryoballoon technique as an alternative has recently evolved.
Journal ArticleDOI
Connexin30.2 containing gap junction channels decelerate impulse propagation through the atrioventricular node
Maria M. Kreuzberg,Jan W. Schrickel,Alexander Ghanem,Jung-Sun Kim,Joachim Degen,Ulrike Janssen-Bienhold,Thorsten Lewalter,Klaus Tiemann,Klaus Willecke +8 more
TL;DR: Results show that mouse connexin30.2 contributes to the slowdown of impulse propagation in the AV node and additionally limits the maximum number of beats conducted from atria to ventricles.