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Birgit Seidelt
Researcher at Ludwig Maximilian University of Munich
Publications - 2
Citations - 427
Birgit Seidelt is an academic researcher from Ludwig Maximilian University of Munich. The author has contributed to research in topics: Transfer RNA & Ribosome-nascent chain complex. The author has an hindex of 2, co-authored 2 publications receiving 402 citations. Previous affiliations of Birgit Seidelt include Center for Integrated Protein Science Munich.
Papers
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Journal ArticleDOI
Structural insight into nascent polypeptide chain-mediated translational stalling.
Birgit Seidelt,C. Axel Innis,Daniel N. Wilson,Marco Gartmann,Jean Paul Armache,Elizabeth Villa,Leonardo G. Trabuco,Thomas Becker,Thorsten Mielke,Thorsten Mielke,Klaus Schulten,Thomas A. Steitz,Thomas A. Steitz,Roland Beckmann +13 more
TL;DR: A model whereby interactions within the tunnel are relayed to the peptidyltransferase center to inhibit translation is proposed, and it is shown that nascent chains adopt distinct conformations within the ribosomal exit tunnel.
Journal ArticleDOI
SecM-stalled ribosomes adopt an altered geometry at the peptidyl transferase center
Shashi Bhushan,Thomas Hoffmann,Birgit Seidelt,Jens Frauenfeld,Thorsten Mielke,Otto Berninghausen,Daniel N. Wilson,Roland Beckmann,Roland Beckmann +8 more
TL;DR: A structure of a ribosome stalled during translation of the SecM peptide provides insight into the mechanism by which the large subunit active site is inactivated.