B
Biserka Kargacin
Researcher at New York University
Publications - 6
Citations - 1032
Biserka Kargacin is an academic researcher from New York University. The author has contributed to research in topics: Chinese hamster & DNA condensation. The author has an hindex of 6, co-authored 6 publications receiving 984 citations.
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Journal ArticleDOI
Mechanisms of Chromium Carcinogenicity and Toxicity
TL;DR: The chemical nature of chromium compounds and how these properties impact upon the interactions ofchromium with cellular and genetic targets, including animal and human hosts, are discussed.
Journal ArticleDOI
Carcinogenic nickel silences gene expression by chromatin condensation and DNA methylation: a new model for epigenetic carcinogens.
Yong-Woo Lee,Catherine B. Klein,Biserka Kargacin,Konstantin Salnikow,Jun Kitahara,Karol Dowjat,Anatoly Zhitkovich,N T Christie,Max Costa +8 more
TL;DR: It is proposed that DNA condensation and methylation result in heterochromatinization of the gpt sequence with subsequent inheritance of the now silenced gene, which further supports the emerging theory that nickel is a human carcinogen that can alter gene expression by enhanced DNA methylation and compaction, rather than by mutagenic mechanisms.
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Mutagenic responses of nickel oxides and nickel sulfides in Chinese hamster V79 cell lines at the xanthine-guanidine phosphoribosyl transferase locus
TL;DR: Mutagenesis of several insoluble nickel compounds--crystalline nickel sulfide NiS, nickel subsulfide Ni3S2, nickel oxides and soluble NiCl2 was studied in three Chinese hamster cell lines--at the hprt gene of the well-defined V79 cell line, and at gpt in two transgenic derivative cell lines G12 and G10.
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Metal mutagenesis in transgenic Chinese hamster cell lines.
TL;DR: In the G12 cells, nickel mutagenesis may be related to the integration of the gpt sequence into a heterochromatic region of the genome, which could not be demonstrated with other metals such as mercury or vanadium.
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Comparison of the uptake and distribution of chromate in rats and mice
TL;DR: Data indicate that species differences exist for Cr metabolism and that they differ with respect to the route of exposure, and may be owing to species differences in the reduction of Cr and different binding of Cr to hemoglobin.