Blake Jones

TL;DR: A novel and relatively simple methodology using polarized light microscopy to image fibrillar structures within a tumour microenvironment, using only linear crossed polarizers is proposed, demonstrating its ability to image and extract measurement-geometry-independent quantitative morphological metrics related to stromal density and alignment in human invasive breast cancer samples.

TL;DR: A novel stromal architecture signature (SAS) methodology based on polarized light imaging that quantifies patterns of tumor connective tissue that demonstrates its ability to differentiate between myxoid and sclerotic stroma, two pathology-derived categories associated with significantly different patient outcomes is presented.

TL;DR: In this paper, a method of imaging intra and peri-tumoural stroma based on polarized light microscopy was proposed to quantify the tumour-stroma ratio (TSR) in human breast cancer.

TL;DR: In this article , the authors used optical coherence angiography (OCA) to measure vessel aggregation at short distances after a single dose of Stereotactic Body Radiotherapy (SBRT).

TL;DR: Prognostic information extracted from the stromal morphology has potential to complement OncotypeDX as an easy‐to‐implement prescreening methodology.