Benzophenone Schiff bases of glycine derivatives: Versatile starting materials for the synthesis of amino acids and their derivatives

ConspectusThe development of highly effective chiral ligands is a key topic in enhancing the catalytic activity and selectivity in metal-catalyzed asymmetric synthesis. Traditionally, the difficult...

The Discovery of Multifunctional Chiral P Ligands for the Catalytic Construction of Quaternary Carbon/Silicon and Multiple Stereogenic Centers.

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Chiral 1,2-Diaminocyclohexane-α-Amino Acid-Derived Amidphos/Ag(I)-Catalyzed Divergent Enantioselective 1,3-Dipolar Cycloaddition of Azomethine Ylides

Brønsted Base and Lewis Acid Cooperatively Catalyzed Asymmetric exo'-Selective [3 + 2] Cycloaddition of Trifluoromethylated Azomethine Ylides and Methyleneindolinones.

A novel (4 + 3) annulation reaction of Morita–Baylis–Hillman carbonates and vinyl benzoxazinanones has been developed by using phosphine/palladium dual catalysis. This reaction demonstrates a wide substrate scope, providing a range of vinyl 2, 3-dihydro-1H-benzo[b]azepine derivatives in moderate to good yields and diastereoselectivities. Experimental results indicate that both palladium and phosphine play crucial roles in the annulation reactions.

Phosphine/Palladium Cooperative Catalysis: (4 + 3) Annulations of Morita-Baylis-Hillman Carbonates and Vinyl Benzoxazinanones.

Enantioselective synthesis of chiral heterocycle derivatives is an important and challenging topic in the field of synthetic chemistry. In this work, the first stereocontrolled dimerization-type homo-1,3-polar [3+2] cycloaddition reaction of glycine aldimino esters for creating new heterocycles bearing multiple stereogenic centers has been developed through the chiral phosphine ligand –involved silver catalysis. A variety of chiral imidazolidines could be obtained with high yields and good diastereoselectivities as well as excellent enantioselectivities by employing Xing-Phos as chiral P-ligand.

Enantioselective Synthesis of Chiral Imidazolidine Derivatives by Asymmetric Silver/Xing-Phos-Catalyzed Homo-1,3-Dipolar [3+2] Cycloaddition of Azomethine Ylides

Ligand-Controlled Inversion of Diastereo- and Enantioselectivity in Silver-Catalyzed Azomethine Ylide–Imine Cycloaddition of Glycine Aldimino Esters with Imines

Bo Yu

Papers

Enantioselective Synthesis of Chiral Imidazolidine Derivatives by Asymmetric Silver/Xing-Phos-Catalyzed Homo-1,3-Dipolar [3+2] Cycloaddition of Azomethine Ylides

Ligand-Controlled Inversion of Diastereo- and Enantioselectivity in Silver-Catalyzed Azomethine Ylide–Imine Cycloaddition of Glycine Aldimino Esters with Imines

Asymmetric Synthesis of Glutamic Acid Derivatives by Silver-Catalyzed Conjugate Addition–Elimination Reactions