B
Boubekeur Samah
Researcher at University of Paris-Sud
Publications - 11
Citations - 1336
Boubekeur Samah is an academic researcher from University of Paris-Sud. The author has contributed to research in topics: Macrophage & Inflammation. The author has an hindex of 10, co-authored 11 publications receiving 1238 citations.
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Journal ArticleDOI
Macrophage activation switching: an asset for the resolution of inflammation
Fabrice Porcheray,Sophie Viaud,Anne-Cécile Rimaniol,Cathie Léone,Boubekeur Samah,Nathalie Dereuddre-Bosquet,Dominique Dormont,Gabriel Gras +7 more
TL;DR: It is found that every activation state was rapidly and fully reversible, suggesting that a given cell may participate sequentially in both the induction and the resolution of inflammation.
Journal ArticleDOI
p21(WAF1) gene promoter is epigenetically silenced by CTIP2 and SUV39H1.
Thomas Cherrier,S Suzanne,L Redel,Miriam Calao,Céline Marban,Boubekeur Samah,Ruma Mukerjee,Christian Schwartz,Gabriel Gras,Bassel E. Sawaya,Steven L. Zeichner,Dominique Aunis,C Van Lint,Olivier Rohr +13 more
TL;DR: The results suggest that CTIP2 is a constitutive p 21 gene suppressor that cooperates with SUV39H1 and histone methylation to silence the p21 gene transcription.
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Macrophage activation and human immunodeficiency virus infection: HIV replication directs macrophages towards a pro-inflammatory phenotype while previous activation modulates macrophage susceptibility to infection and viral production.
TL;DR: The results emphasize that HIV infection of macrophages sets up inflammation at the cell level but through unexpected mechanisms, which may limit target susceptibility and participate in virus clearance but may also result in tissue damage.
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Characterization of human monocyte-derived microglia-like cells.
Cathie Léone,Gwenaelle Le Pavec,William Même,Fabrice Porcheray,Boubekeur Samah,Dominique Dormont,Gabriel Gras +6 more
TL;DR: A convenient cellular model for human microglia, suitable for HIV studies, is developed from human monocytes and may help to better understand HIV‐associated microgliosis and chronic inflammation in the brain.
Journal ArticleDOI
The glutamate‐glutamine cycle as an inducible, protective face of macrophage activation
TL;DR: The possible neuroprotective and neurotrophic roles of activated microglia and brain macrophages (AMM) and their relationships with inflammation and oxidative stress are discussed.