Ruma Mukerjee

TL;DR: The results suggest that CTIP2 is a constitutive p 21 gene suppressor that cooperates with SUV39H1 and histone methylation to silence the p21 gene transcription.

TL;DR: The results point to the activation of hypoxia-inducible factor 1 (HIF-1) upon HIV-1 infection and its elevation in brain cells of AIDS patients with dementia and that, by inducing oxidative stress via activation of Hif-1, Vpr can induce HIV- 1 gene expression and dysregulate multiple host cellular pathways.

TL;DR: This review will address p53 functions as it relates to various neurodegenerative diseases, mainly its implications in the development of HIV-associated neurocognitive disorders and inhibition of p53 may present an ideal target to restore neuronal functions.

TL;DR: It is concluded that deregulation of neuronal functions by HIV-1 Tat protein is miRNA-dependent, thereby contributing to neuronal deregulation and AIDS dementia.

TL;DR: It is concluded that Vpr plays a major role in neuronal dysfunction through deregulating microRNAs and their target genes, a phenomenon that could lead to the development of neurocognitive disorders.