B
Bram D. van Rhijn
Researcher at Utrecht University
Publications - 27
Citations - 793
Bram D. van Rhijn is an academic researcher from Utrecht University. The author has contributed to research in topics: Eosinophilic esophagitis & Incidence (epidemiology). The author has an hindex of 13, co-authored 27 publications receiving 645 citations. Previous affiliations of Bram D. van Rhijn include University Medical Center Utrecht & University of Amsterdam.
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Journal ArticleDOI
Proton pump inhibitors partially restore mucosal integrity in patients with proton pump inhibitor-responsive esophageal eosinophilia but not eosinophilic esophagitis.
Bram D. van Rhijn,Pim W. Weijenborg,Joanne Verheij,Marius A. van den Bergh Weerman,Caroline Verseijden,Rene M. van den Wijngaard,Wouter J. de Jonge,Andreas J. Smout,Albert J. Bredenoord +8 more
TL;DR: The integrity of the esophageal mucosa is impaired in patients with EoE and PPI-REE, allowing transepithelial transport of small molecules and acid reflux-induced esophagal mucosal damage that promotes transe Pithelial flux of allergens.
Journal ArticleDOI
Long-Term Loss of Response in Proton Pump Inhibitor-Responsive Esophageal Eosinophilia Is Uncommon and Influenced by CYP2C19 Genotype and Rhinoconjunctivitis.
Javier Molina-Infante,Joaquín Rodríguez-Sánchez,Jan Martinek,Bram D. van Rhijn,Jana Krajciova,Maria D. Rivas,Jesús Barrio,Fouad J. Moawad,Carmen Martinez-Alcala,Albert J. Bredenoord,José Luis Zamorano,Evan S. Dellon +11 more
TL;DR: Most PPI-REE patients remain in long-term remission on low-dose PPI therapy, and patients frequently responded to PPI dose escalation.
Journal ArticleDOI
Evaluating the Endoscopic Reference Score for eosinophilic esophagitis: moderate to substantial intra- and interobserver reliability
Bram D. van Rhijn,Marijn J. Warners,Wouter L. Curvers,Anja U. van Lent,Noor L. Bekkali,R. Bart Takkenberg,Jaap J. Kloek,Jacques J. Bergman,Paul Fockens,Albert J. Bredenoord +9 more
TL;DR: Using the EREFS, endoscopic signs of eosinophilic esophagitis were scored consistently by expert and trainee endoscopists and inter- and intraobserver agreement was not substantially different between expert andTrainee endoscopeopists.
Journal ArticleDOI
Prevalence of esophageal motility abnormalities increases with longer disease duration in adult patients with eosinophilic esophagitis
TL;DR: The relationship between disease duration, clinical characteristics, and manometric pattern of EoE patients was studied to determine the risk for esophageal stricture formation and motility abnormalities.
Journal ArticleDOI
Histological Response to Fluticasone Propionate in Patients With Eosinophilic Esophagitis Is Associated With Improved Functional Esophageal Mucosal Integrity.
Bram D. van Rhijn,Joanne Verheij,Marius A. van den Bergh Weerman,Caroline Verseijden,Rene M. van den Wijngaard,Wouter J. de Jonge,Andreas J. Smout,Albert J. Bredenoord +7 more
TL;DR: Improvement of the mucosal barrier integrity correlates with normalization of expression of desmoglein-1 and filaggrin marker genes and reduces eosinophilic inflammation in adult EoE patients.