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Anja U. van Lent
Researcher at University of Amsterdam
Publications - 12
Citations - 1296
Anja U. van Lent is an academic researcher from University of Amsterdam. The author has contributed to research in topics: Haematopoiesis & Progenitor cell. The author has an hindex of 10, co-authored 11 publications receiving 828 citations. Previous affiliations of Anja U. van Lent include Bill & Melinda Gates Foundation & Netherlands Cancer Institute.
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Journal ArticleDOI
Neoadjuvant immunotherapy leads to pathological responses in MMR-proficient and MMR-deficient early-stage colon cancers.
Myriam Chalabi,Lorenzo F. Fanchi,Krijn K. Dijkstra,José G van den Berg,Arend G. J. Aalbers,Karolina Sikorska,Marta Lopez-Yurda,Cecile Grootscholten,Geerard L. Beets,Geerard L. Beets,Petur Snaebjornsson,Monique Maas,Marjolijn Mertz,Vivien Veninga,Gergana Bounova,Annegien Broeks,Regina G. H. Beets-Tan,Regina G. H. Beets-Tan,Thomas R de Wijkerslooth,Anja U. van Lent,Hendrik A Marsman,Elvira Nuijten,Niels F. M. Kok,Maria Kuiper,Wieke H M Verbeek,Marleen Kok,Monique E. van Leerdam,Ton N. Schumacher,Emile E. Voest,John B. A. G. Haanen +29 more
TL;DR: The data indicate that neoadjuvant immunotherapy may have the potential to become the standard of care for a defined group of colon cancer patients when validated in larger studies with at least 3 years of disease-free survival data.
Journal ArticleDOI
Humanized mice for modeling human infectious disease: challenges, progress, and outlook.
Nicolas Legrand,Nicolas Legrand,Alexander Ploss,Alexander Ploss,Rudi Balling,Pablo D. Becker,Chiara Borsotti,Nicolas Brezillon,Nicolas Brezillon,Jennifer Debarry,Ype P. de Jong,Ype P. de Jong,Hongkui Deng,Hongkui Deng,James P. Di Santo,James P. Di Santo,Stephanie C. Eisenbarth,Stephanie C. Eisenbarth,Elizabeth E. Eynon,Elizabeth E. Eynon,Richard A. Flavell,Richard A. Flavell,Carlos A. Guzmán,Nicholas D. Huntington,Nicholas D. Huntington,Dina Kremsdorf,Dina Kremsdorf,Michael Manns,Michael Manns,Markus G. Manz,Jean Jacques Mention,Jean Jacques Mention,Michael Ott,Michael Ott,Chozhavendan Rathinam,Chozhavendan Rathinam,Charles M. Rice,Charles M. Rice,Anthony Rongvaux,Anthony Rongvaux,Sean Stevens,Sean Stevens,Hergen Spits,Hergen Spits,Hélène Strick-Marchand,Hélène Strick-Marchand,Hitoshi Takizawa,Anja U. van Lent,Anja U. van Lent,Chengyan Wang,Chengyan Wang,Kees Weijer,Kees Weijer,Tim Willinger,Tim Willinger,Patrick Ziegler +55 more
TL;DR: The potential and challenges of humanized mouse models for developing effective and affordable therapies and vaccines, which are desperately needed to combat these diseases, are discussed.
Journal ArticleDOI
IL-7 Enhances Thymic Human T Cell Development in “Human Immune System” Rag2−/−IL-2Rγc−/− Mice without Affecting Peripheral T Cell Homeostasis
Anja U. van Lent,Wendy Dontje,Maho Nagasawa,Rachida Siamari,Arjen Q. Bakker,Stephan M. Pouw,Kelly Maijoor,Kees Weijer,Jan J. Cornelissen,Bianca Blom,James P. Di Santo,Hergen Spits,Nicolas Legrand +12 more
TL;DR: It is shown that premature IL-7 signaling at the HSC stage, before entrance in the thymus, impeded T cell development, whereas increased intrathymic IL- 7 signaling significantly enhanced the maintenance of immature thymocytes.
Journal ArticleDOI
Transient accumulation of human mature thymocytes and regulatory T cells with CD28 superagonist in "human immune system" Rag2 -/- γc -/- mice
Nicolas Legrand,Nicolas Legrand,Tom Cupedo,Tom Cupedo,Anja U. van Lent,Anja U. van Lent,Menno J. Ebeli,Menno J. Ebeli,Kees Weijer,Kees Weijer,Thomas Hanke,Thomas Hanke,Hergen Spits,Hergen Spits +13 more
TL;DR: Results show that superagonist anti-CD28 treatment transiently induces a 7-fold increase in thymocyte numbers and up to 18-fold accumulation of mature thymocytes, which could be of clinical interest in humans, both for beneficial effect on thymic T- cell production as well as regulatory T-cell accumulation.
Journal ArticleDOI
Evaluating the Endoscopic Reference Score for eosinophilic esophagitis: moderate to substantial intra- and interobserver reliability
Bram D. van Rhijn,Marijn J. Warners,Wouter L. Curvers,Anja U. van Lent,Noor L. Bekkali,R. Bart Takkenberg,Jaap J. Kloek,Jacques J. Bergman,Paul Fockens,Albert J. Bredenoord +9 more
TL;DR: Using the EREFS, endoscopic signs of eosinophilic esophagitis were scored consistently by expert and trainee endoscopists and inter- and intraobserver agreement was not substantially different between expert andTrainee endoscopeopists.