W
Wouter J. de Jonge
Researcher at University of Amsterdam
Publications - 172
Citations - 4977
Wouter J. de Jonge is an academic researcher from University of Amsterdam. The author has contributed to research in topics: Medicine & Biology. The author has an hindex of 32, co-authored 120 publications receiving 4005 citations. Previous affiliations of Wouter J. de Jonge include University of Bonn & VU University Amsterdam.
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Journal ArticleDOI
Stimulation of the vagus nerve attenuates macrophage activation by activating the Jak2-STAT3 signaling pathway.
Wouter J. de Jonge,Esmerij P. van der Zanden,Maarten F. Bijlsma,David J van Westerloo,Roelof J. Bennink,Hans-Rudolf Berthoud,Satoshi Uematsu,Shizuo Akira,Rene M. van den Wijngaard,Guy E. Boeckxstaens +9 more
TL;DR: In a mouse model of intestinal manipulation, stimulation of the vagus nerve ameliorated surgery-induced inflammation and postoperative ileus by activating STAT3 in intestinal macrophages and it is concluded that the vagal anti-inflammatory pathway acts by α7 subunit–mediated Jak2-STAT3 activation.
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Chemokine CXCL13 is essential for lymph node initiation and is induced by retinoic acid and neuronal stimulation.
Serge A. van de Pavert,Brenda J. Olivier,Gera Goverse,Mark F. R. Vondenhoff,Mascha Greuter,Patrick Beke,Kim Kusser,Uta E. Höpken,Martin Lipp,Karen Niederreither,Rune Blomhoff,Kasia Sitnik,William W. Agace,Troy D. Randall,Wouter J. de Jonge,Reina E. Mebius +15 more
TL;DR: The data show that the initiation of lymph node development is controlled by RA-mediated expression of CXCL13 and suggest that RA may be provided by adjacent neurons, and show that parasymphathetic neural output in adults led to RA receptor (RAR)-dependent induction of CxCL13 in the gut.
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Postoperative ileus is maintained by intestinal immune infiltrates that activate inhibitory neural pathways in mice.
Wouter J. de Jonge,Rene M. van den Wijngaard,Merel-Linde Ter Beek,Roel J. Bennink,Guido N. J. Tytgat,Ruud M. Buijs,Pieter H. Reitsma,Sander J. H. van Deventer,Guy E. Boeckxstaens +8 more
TL;DR: In this paper, the authors studied the pathophysiology of postoperative gastroparesis after abdominal surgery in a murine model by determining gastric emptying after manipulation of the small intestine.
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Proton pump inhibitors partially restore mucosal integrity in patients with proton pump inhibitor-responsive esophageal eosinophilia but not eosinophilic esophagitis.
Bram D. van Rhijn,Pim W. Weijenborg,Joanne Verheij,Marius A. van den Bergh Weerman,Caroline Verseijden,Rene M. van den Wijngaard,Wouter J. de Jonge,Andreas J. Smout,Albert J. Bredenoord +8 more
TL;DR: The integrity of the esophageal mucosa is impaired in patients with EoE and PPI-REE, allowing transepithelial transport of small molecules and acid reflux-induced esophagal mucosal damage that promotes transe Pithelial flux of allergens.
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Intestinal Fungal Dysbiosis Is Associated With Visceral Hypersensitivity in Patients With Irritable Bowel Syndrome and Rats
Sara Botschuijver,Guus Roeselers,Evgeni Levin,Daisy Jonkers,Olaf Welting,Sigrid E.M. Heinsbroek,Heleen H. de Weerd,Teun Boekhout,Teun Boekhout,Matteo Fornai,Matteo Fornai,Ad A.M. Masclee,Frank H. J. Schuren,Wouter J. de Jonge,Jurgen Seppen,Rene M. van den Wijngaard +15 more
TL;DR: In studies of rats, the authors found fungi to promote visceral hypersensitivity, which could be reduced by administration of fungicides, soluble β-glucans, or a SYK inhibitor, and the intestinal fungi might therefore be manipulated for treatment of IBS-related visceral hypers sensitivity.