Showing papers by "Branca M. Silva published in 2022"
TL;DR: In this paper , the current state of implementation of the Quality by Design (QbD) approach in the pharmaceutical development of lipid-based nanosystems is surveyed. And a survey of current trends of risk assessment tools, design of experiments (DoE) methodologies, and characterization techniques applied to the development of these products is provided.
5 citations
TL;DR: Oxidative stress has been associated with decreased sperm quality and male infertility and should be considered as a major cause of infertility in men.
Abstract: Oxidative stress has been associated with decreased sperm quality and male infertility [...].
2 citations
TL;DR: This review aims to contribute to the biological understanding of the molecular transformations induced by obesogens that are the basis of male infertility, shaped by the use of Adverse Outcomes Pathways, a new approach that may shift the paradigm of reproductive toxicology.
Abstract: The permanent exposure to environmental contaminants promoting weight gain (i.e., obesogens) has raised serious health concerns. Evidence suggests that obesogens are one of the leading causes of the marked decline in male fertility and are key players in shaping future health outcomes, not only for those who are directly exposed to them, but also for upcoming generations. It has been hypothesized that obesogens affect male fertility. By using an interdisciplinary strategy, combining in silico, in vitro, in vivo and epidemiological findings, this review aims to contribute to the biological understanding of the molecular transformations induced by obesogens that are the basis of male infertility. Such understanding is shaped by the use of Adverse Outcomes Pathways, a new approach that may shift the paradigm of reproductive toxicology, contributing to the improvement of the diagnosis and management of the adverse effects of obesogens in male fertility.
1 citations
1 citations
TL;DR: A searchable abstracts of presentations at key conferences in endocrinology can be found in this article , where the abstracts are extracted from the corresponding abstracts from the conference proceedings.
Abstract: Searchable abstracts of presentations at key conferences in endocrinology ISSN 1470-3947 (print) | ISSN 1479-6848 (online)