B
Brandon J. Biesiadecki
Researcher at Ohio State University
Publications - 87
Citations - 2359
Brandon J. Biesiadecki is an academic researcher from Ohio State University. The author has contributed to research in topics: Troponin I & Myofilament. The author has an hindex of 29, co-authored 78 publications receiving 1983 citations. Previous affiliations of Brandon J. Biesiadecki include Case Western Reserve University & Northwestern University.
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Journal ArticleDOI
Ranolazine, a partial fatty acid oxidation (pFOX) inhibitor, improves left ventricular function in dogs with chronic heart failure * **
Hani N. Sabbah,Margaret P. Chandler,Takayuki Mishima,George Suzuki,Pervaiz A. Chaudhry,Omar Nass,Brandon J. Biesiadecki,Brent Blackburn,Andrew A. Wolff,William C. Stanley +9 more
TL;DR: In dogs with HF, acute intravenous administration of the pFOX inhibitor ranolazine improves LV systolic function and suggests that the drug is devoid of any positive inotropic effects and acts primarily by optimizing cardiac metabolism in the setting of chronic HF.
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The Troponin C G159D Mutation Blunts Myofilament Desensitization Induced by Troponin I Ser23/24 Phosphorylation
TL;DR: Novel evidence is provided that modification of the cTnC-cTnI interaction has distinct effects on troponin Ca2+-binding and cross-bridge kinetics to suggest a novel role for thin filament mutations in the modulation of myofilament function through &bgr;-adrenergic signaling as well as the development of cardiomyopathy.
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Selective deletion of the NH2-terminal variable region of cardiac troponin T in ischemia-reperfusion by myofibril-associated μ-calpain cleavage
TL;DR: With the functional consequences of removing the NH2-terminal variable region of TnT, the mu-calpain-mediated proteolytic modification of TNT may act as an acute mechanism to adjust muscle contractility under stress conditions.
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Adenosine-Induced Atrial Fibrillation: Localized Reentrant Drivers in Lateral Right Atria due to Heterogeneous Expression of Adenosine A1 Receptors and GIRK4 Subunits in the Human Heart.
Ning Li,Thomas A. Csepe,Brian J. Hansen,Lidiya V. Sul,Anuradha Kalyanasundaram,Stanislav O. Zakharkin,Jichao Zhao,Avirup Guha,David R. Van Wagoner,Ahmet Kilic,Peter J. Mohler,Paul M.L. Janssen,Brandon J. Biesiadecki,John D. Hummel,Raul Weiss,Vadim V. Fedorov +15 more
TL;DR: A 3-fold RA-to-LA adenosine A1 receptor protein expression gradient in the human heart is revealed, leading to significantly greater RA versus LA repolarization sensitivity in response toadenosine.
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Redundant and diverse intranodal pacemakers and conduction pathways protect the human sinoatrial node from failure.
Ning Li,Brian J. Hansen,Thomas A. Csepe,Jichao Zhao,Anthony J. Ignozzi,Lidiya V. Sul,Stanislav O. Zakharkin,Anuradha Kalyanasundaram,Jonathan P. Davis,Brandon J. Biesiadecki,Ahmet Kilic,Paul M.L. Janssen,Peter J. Mohler,Raul Weiss,John D. Hummel,Vadim V. Fedorov +15 more
TL;DR: The results unmasked reserve mechanisms that protect the human SAN pacemaker and conduction complex from rhythm failure, which may contribute to treatment of SAN arrhythmias.