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Brandon S. Klinedinst
Researcher at Iowa State University
Publications - 20
Citations - 117
Brandon S. Klinedinst is an academic researcher from Iowa State University. The author has contributed to research in topics: Medicine & Internal medicine. The author has an hindex of 4, co-authored 12 publications receiving 36 citations.
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Journal ArticleDOI
Cholecystokinin and Alzheimer's disease: a biomarker of metabolic function, neural integrity, and cognitive performance
Alexandra K. Plagman,Siobhan M. Hoscheidt,Kelsey E. McLimans,Brandon S. Klinedinst,Colleen Pappas,Vellareddy Anantharam,Anumantha G. Kanthasamy,Auriel A. Willette,Alzheimer’s Disease Neuroimaging Initiative +8 more
TL;DR: Higher CCK levels may reflect compensatory protection as AD pathology progresses and be a useful marker of cognitive and neural integrity in participants with normal cognition, mild cognitive impairment, and Alzheimer's disease.
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Genetic Factors of Alzheimer’s Disease Modulate How Diet is Associated with Long-Term Cognitive Trajectories: A UK Biobank Study
Brandon S. Klinedinst,Scott T. Le,Brittany Larsen,Colleen Pappas,Nathan Hoth,Amy Pollpeter,Qian Wang,Yueying Wang,Shan Yu,Li Wang,Karin Allenspach,Jonathan P. Mochel,David A. Bennett,Auriel A. Willette +13 more
TL;DR: Modifying meal plans may help minimize cognitive decline, and observations suggest in risk status-dependent manners that adding cheese and red wine to the diet daily, and lamb on a weekly basis, may also improve long-term cognitive outcomes.
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Is Cerebrospinal Fluid Superoxide Dismutase 1 a Biomarker of Tau But Not Amyloid-Induced Neurodegeneration in Alzheimer's Disease?
Kelsey E. McLimans,Bridget E Clark,Alexandra K. Plagman,Colleen Pappas,Brandon S. Klinedinst,Vellareddy Anatharam,Anumantha G. Kanthasamy,Auriel A. Willette +7 more
TL;DR: Copper/zinc superoxide dismutase 1 scavenges free radicals that may otherwise damage brain parenchyma and drives Alzheimer's disease (AD) neuropathology in anima...
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Aging-related changes in fluid intelligence, muscle and adipose mass, and sex-specific immunologic mediation: A longitudinal UK Biobank study
Brandon S. Klinedinst,Colleen Pappas,Scott T. Le,Shan Yu,Qian Wang,Li Wang,Karin Allenspach-Jorn,Jonathan P. Mochel,Auriel A. Willette +8 more
TL;DR: Exercise studies in older adults may benefit from assessing sex-specific values of DEXA-based tissue mass, FI, and leukocyte sub-populations to gauge potential cognitive benefits of less VAM and more LMM.
Journal ArticleDOI
Inflammation, negative affect, and amyloid burden in Alzheimer's disease: Insights from the kynurenine pathway.
Auriel A. Willette,Colleen Pappas,Nathan Hoth,Qian Wang,Brandon S. Klinedinst,Sara A. Willette,Brittany Larsen,Amy Pollpeter,Tianqi Li,Scott T. Le,Ana D. Collazo-Martinez,Jonathan P. Mochel,Karin Allenspach,Robert Dantzer +13 more
TL;DR: This paper found that inflammatory signaling cascades may occur during Alzheimer's disease, which is associated with increased Kyn metabolism that influences the pathogenesis of negative affect, and the complement system may be critical contributing factors in this process.