B
Brant Clayton Boren
Researcher at Exelixis
Publications - 5
Citations - 126
Brant Clayton Boren is an academic researcher from Exelixis. The author has contributed to research in topics: Liver X receptor & Whole blood. The author has an hindex of 3, co-authored 5 publications receiving 121 citations.
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Patent
LXR and FXR Modulators
Brant Clayton Boren,Brett B. Busch,Xiao-Hui Gu,Vasu Jammalamadaka,Shao Po Lu,Richard Martin,Raju Mohan,Edwin Schweiger,William C. Stevens,Tie-Lin Wang,Yinong Xie,Wei Xu +11 more
TL;DR: In this article, the authors proposed a modulator of the activity of liver X receptors (LXR) and Farnesoid X receptor (FXR), where R00, R200, R400, R500, J11, J21, G1, G21, and Q are defined.
Patent
Triazole and imidazole derivatives for use as tgr5 agonists in the treatment of diabetes and obesity
Bollu Venkataiah,Brant Clayton Boren,Jackaline Dalgard Julien,Brenton T. Flatt,Nadia Haq,Sarah Hudson,Raju Mohan,Morrissey Michael M,Benjamin Anthony Pratt,Tie-Lin Wang,Martin Richard,Xiao-Hui Gu +11 more
TL;DR: In this paper, TGR5 agonists of structural formula I, wherein X, R1, R2, and R5 are defined herein, as well as N-oxides of them and pharmaceutically acceptable salts thereof.
Journal ArticleDOI
Discovery of Highly Potent Liver X Receptor β Agonists.
Ellen K. Kick,Brett B. Busch,Richard Martin,William C. Stevens,Venkataiah Bollu,Yinong Xie,Brant Clayton Boren,Michael Charles Nyman,Max H. Nanao,Lam Nguyen,Artur Plonowski,Ira G. Schulman,Grace Yan,Huiping Zhang,Xiaoping Hou,Meriah Neissel Valente,Rangaraj Narayanan,Kamelia Behnia,A. David Rodrigues,Barry Brock,James Smalley,Glenn H. Cantor,John A. Lupisella,Paul G. Sleph,Denise Grimm,Jacek Ostrowski,Ruth R. Wexler,Todd G. Kirchgessner,Raju Mohan +28 more
TL;DR: The agonist series demonstrated robust LXRβ activity (>70%) with low partial LXRα agonist activity (<25%) in cell assays, providing a window between desired blood cell ABCG1 gene induction in cynomolgus monkeys and modest elevation of plasma triglycerides for agonist 15.
Patent
Agonistes de tgr5
Venkataiah Bollu,Brant Clayton Boren,Jackline Eve Dalgard,Brenton T. Flatt,Nadia Haq,Sarah Hudson,Raju Mohan,Morrissey Michael M,Benjamin Anthony Pratt +8 more
TL;DR: The authors concerne des agonistes de TGR5 de formule developpee VIII(Q), ou X, R 1, R 2, and R 5 sont definis dans la description, leurs sels pharmaceutiquement acceptables, des compositions les contenant, et l'utilisation des composes et des compositions pour traiter des pathologies.
Patent
Dérivés de triazole et d'imidazole destinés à être utilisés en tant qu'agonistes de tgr5 dans le traitement du diabète et de l'obésité
Venkataiah Bollu,Brant Clayton Boren,Jackline Eve Dalgard,Brenton T. Flatt,Nadia Haq,Sarah Hudson,Raju Mohan,Morrissey Michael M,Benjamin Anthony Pratt,Tie-Lin Wang +9 more
TL;DR: In this paper, the authors present an invention porte sur des agonistes de TGR5 de la formule structurale I, dans laquelle X, R 1, R 2, and R 5 sont definis par les presentes, ainsi que sur leurs N-oxydes and les sels de qualite pharmaceutique of ces composes and N-oxideydes.