T
Todd G. Kirchgessner
Researcher at Bristol-Myers Squibb
Publications - 56
Citations - 6881
Todd G. Kirchgessner is an academic researcher from Bristol-Myers Squibb. The author has contributed to research in topics: Lipoprotein lipase & Peptide sequence. The author has an hindex of 36, co-authored 56 publications receiving 6366 citations. Previous affiliations of Todd G. Kirchgessner include University of California, Los Angeles.
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Journal ArticleDOI
A novel human hepatic organic anion transporting polypeptide (OATP2). Identification of a liver-specific human organic anion transporting polypeptide and identification of rat and human hydroxymethylglutaryl-CoA reductase inhibitor transporters.
Bonnie Hsiang,Yingjie Zhu,Zhaoqing Wang,Yuli Wu,Vito G. Sasseville,Wen-Pin Yang,Todd G. Kirchgessner +6 more
TL;DR: OATP2 is a novel organic anion transport protein that has overlapping but not identical substrate specificities with each of the other subtypes and, with its liver-specific expression, represents a functionally distinct OATP isoform.
Journal ArticleDOI
Comparative Analysis of Proteome and Transcriptome Variation in Mouse
Anatole Ghazalpour,Brian J. Bennett,Vladislav A. Petyuk,Luz D. Orozco,Raffi Hagopian,Imran N. Mungrue,Charles R. Farber,Janet S. Sinsheimer,Hyun Min Kang,Nicholas A. Furlotte,Christopher C. Park,Ping Zi Wen,Heather M. Brewer,Karl K. Weitz,David G. Camp,Calvin Pan,Roumyana Yordanova,Isaac M. Neuhaus,Charles Tilford,Nathan O. Siemers,Peter S. Gargalovic,Eleazar Eskin,Todd G. Kirchgessner,Desmond J. Smith,Richard D. Smith,Aldons J. Lusis +25 more
TL;DR: Using correlation analysis, it is found that a low number of clinical trait relationships are preserved between the protein and mRNA gene products and that the majority of such relationships are specific to either the protein levels or transcript levels.
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Genetic Control of Obesity and Gut Microbiota Composition in Response to High-Fat, High-Sucrose Diet in Mice
Brian W. Parks,Elizabeth Nam,Elin Org,Emrah Kostem,Frode Norheim,Frode Norheim,Simon T. Hui,Calvin Pan,Mete Civelek,Christoph Rau,Brian J. Bennett,Brian J. Bennett,Margarete Mehrabian,Luke K. Ursell,Aiqing He,Lawrence W. Castellani,Bradley A. Zinker,Mark S. Kirby,Thomas A. Drake,Christian A. Drevon,Rob Knight,Rob Knight,Peter S. Gargalovic,Todd G. Kirchgessner,Eleazar Eskin,Aldons J. Lusis +25 more
TL;DR: It is shown that HF/HS feeding promotes robust, strain-specific changes in obesity that are not accounted for by food intake and provided evidence for a genetically determined set point for obesity.
Journal ArticleDOI
Human lipoprotein lipase complementary DNA sequence
TL;DR: Analysis of the sequence indicates that human lipoprotein lipase, hepaticlipase, and pancreatic lipase are members of a gene family that acts to hydrolyze triglycerides, providing free fatty acids for cells and affecting the maturation of circulating lipoproteins.
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The Unfolded Protein Response Is an Important Regulator of Inflammatory Genes in Endothelial Cells
Peter S. Gargalovic,Nima M. Gharavi,Michael J. Clark,Joanne Pagnon,Wen-Pin Yang,Aiqing He,Amy Truong,Tamar Baruch-Oren,Judith A. Berliner,Todd G. Kirchgessner,Aldons J. Lusis +10 more
TL;DR: The data suggest that the UPR pathway is a general mediator of vascular inflammation and EC dysfunction in atherosclerosis, and, likely, other inflammatory disorders.