Showing papers by "Brenda J. Tripathi published in 1994"
TL;DR: The present findings support the concept of the intraocular derivation of this cytokine and hypothesize that the increased level of TGF-β2 in the aqueous humor of POAG patients causes a decrease in the cellularity of the trabecular meshwork and promotes the buildup of excessive amounts of ECM materials that are characteristic of this disease and contribute to the increased resistance to aQueous outflow.
511 citations
TL;DR: It is hypothesized that abnormal changes in the production of TGF-beta s by trabecular cells and/or in the activation of these growth modulators contribute to the excess accumulation of extracellular matrix components in the aqueous outflow system as observed in aging and glaucomatous eyes.
76 citations
67 citations
TL;DR: The results show that the trabecular meshwork contains a significant amount of type VI collagen and that trABecular cells express the mRNA coding for the alpha 2(VI) chain of this glycoprotein.
19 citations
TL;DR: The finding of ectopic iris muscle is consistent with avian chimera experiments that have suggested that iris sphincter muscle is derived from the neural crest, not neural ectoderm, and suggests that congenital pupillary-iris-lens membrane with goniodysgenesis is a neurocristopathy.
Abstract: A pupillary membrane in a case of congenital pupillary-iris-lens membrane with goniodysgenesis was surgically peeled from the lens without causing cataract formation. Histopathology revealed ectopic iris. The ectopic iris found in this condition differentiates congenital pupillary-iris-lens membrane with goniodysgenesis as an entity from persistent pupillary membrane, hereditary goniodysgenesis, and Rieger's anomaly. We suggest that congenital pupillary-iris-lens membrane with goniodysgenesis is a neurocristopathy. The finding of ectopic iris muscle is consistent with avian chimera experiments that have suggested that iris sphincter muscle is derived from the neural crest, not neural ectoderm. Membranes in this condition can be successfully removed when they cause vision loss and amblyopia.
14 citations