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Brent Johnston
Researcher at Dalhousie University
Publications - 68
Citations - 4692
Brent Johnston is an academic researcher from Dalhousie University. The author has contributed to research in topics: Chemokine & Natural killer T cell. The author has an hindex of 34, co-authored 63 publications receiving 4259 citations. Previous affiliations of Brent Johnston include Halifax & University of Calgary.
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Journal ArticleDOI
A minimal role for selectins in the recruitment of leukocytes into the inflamed liver microvasculature.
TL;DR: It is demonstrated for the first time that selectins are not an essential step for leukocyte recruitment into the inflamed liver microvasculature.
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Bonzo/CXCR6 expression defines type 1–polarized T-cell subsets with extralymphoid tissue homing potential
Chang H. Kim,Eric J. Kunkel,Judie Boisvert,Brent Johnston,James Campbell,Mark C. Genovese,Harry B. Greenberg,Eugene C. Butcher +7 more
TL;DR: It is shown that newly identified chemokine receptor Bonzo/CXCR6 is expressed by subsets of Th1 or T-cytotoxic 1 (Tc1) cells, but not by Th2 or Tc2 cells, establishing Bonzo as a differential marker of polarized type 1 T cells in vitro and in vivo.
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Trafficking machinery of NKT cells: shared and differential chemokine receptor expression among Vα24+Vβ11+ NKT cell subsets with distinct cytokine-producing capacity
TL;DR: It is concluded that, unlike conventional naive, memory, or effector T cells, the entire N KT cell population expresses nonlymphoid tissue homing chemokine receptors, yet NKT cell subsets differ considerably from each other by displaying distinct and reciprocal expression patterns of some chemokin receptors.
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A Common Mucosal Chemokine (Mucosae-Associated Epithelial Chemokine/CCL28) Selectively Attracts IgA Plasmablasts
Nicole H. Lazarus,Eric J. Kunkel,Brent Johnston,Eric Wilson,Kenneth R. Youngman,Eugene C. Butcher +5 more
TL;DR: It is demonstrated that the mucosae-associated epithelial chemokine, MEC (CCL28), is selectively chemotactic for IgA Ab-secreting cells (ASC), and a broad and unifying role for MEC in the physiology of the mucosal IgA immune system is suggested.
Journal ArticleDOI
Chemokines in rapid leukocyte adhesion triggering and migration
Brent Johnston,Eugene C. Butcher +1 more
TL;DR: The regulated expression of chemokines and their receptors is a critical determinant for homing of specialized lymphocyte subsets, and controls both tissue and inflammation-specific immune processes.