Brian D. Palmer

TL;DR: P pH-responsive biomaterials bring forth conformational changes in these nanocarriers through various mechanisms such as protonation, charge reversal or cleavage of a chemical bond, facilitating tumour specific cell uptake or drug release, helping to design more efficient drug delivery systems.

TL;DR: A series of 6- and 7-acrylamide derivatives of the 4-(phenylamino)quinazoline and -pyridopyrimidine classes of epidermal growth factor receptor (EGFR) inhibitors showed significant tumor growth inhibition (stasis) over a dose range, and the poor aqueous solubility of the compounds was a drawback.

TL;DR: Metal complexes of nitrogen mustards have significant hypoxic selectivity toward mammalian cells in cell culture and are a new general class of hypoxia-selective cytotoxins.

TL;DR: Results are consistent with structure-activity relationship studies previously developed for the 4-[(3-bromophenyl)amino] quinazolines, which suggested that small electron-donating substituents at the 6- and 7-positions were desirable for high potency.

TL;DR: Select compounds were evaluated for their ability to inhibit EGFR autophosphorylation in A431 cells, and a positive quantitative correlation was found between this activity and inhibitory activity against the isolated enzyme.