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Brian F. Thomas
Researcher at Research Triangle Park
Publications - 135
Citations - 6459
Brian F. Thomas is an academic researcher from Research Triangle Park. The author has contributed to research in topics: Cannabinoid & Cannabinoid receptor. The author has an hindex of 36, co-authored 129 publications receiving 5889 citations. Previous affiliations of Brian F. Thomas include Virginia Commonwealth University & RTI International.
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Journal ArticleDOI
Bisphenol A Exposure Causes Meiotic Aneuploidy in the Female Mouse
Patricia A. Hunt,Kara E. Koehler,Martha Susiarjo,Craig A. Hodges,Arlene Ilagan,Robert C. Voigt,Sally Thomas,Brian F. Thomas,Terry J. Hassold +8 more
TL;DR: These results provide the first unequivocal link between mammalian meiotic aneuploidy and an accidental environmental exposure and suggest that the oocyte and its meiotic spindle will provide a sensitive assay system for the study of reproductive toxins.
Journal ArticleDOI
Three-Generation Reproductive Toxicity Study of Dietary Bisphenol A in CD Sprague-Dawley Rats
Rochelle W. Tyl,Christina B. Myers,Melissa C. Marr,Brian F. Thomas,Alison R. Keimowitz,Dolores R. Brine,Milan Veselica,Patricia A. Fail,Tsai-Ying Chang,John C. Seely,R. L. Joiner,John H. Butala,Stephen Dimond,Stuart Cagen,R. N. Shiotsuka,Gisela D. Stropp,John M. Waechter +16 more
TL;DR: BPA should not be considered a selective reproductive toxicant, based on the results of this study, and no evidence of nonmonotonic dose-response curves across generations for either sex is found.
Journal ArticleDOI
Behavioral, biochemical, and molecular modeling evaluations of cannabinoid analogs.
Billy R. Martin,D R Compton,Brian F. Thomas,W. R. Prescott,P. J. Little,Raj K. Razdan,M R Johnson,L S Melvin,Raphael Mechoulam,S. J. Ward +9 more
TL;DR: The structural diversity and wide-ranging potencies of the analogs described herein provide the opportunity to develop a pharmacophore for the cannabinoids using molecular modeling techniques.
Journal ArticleDOI
Labeling Accuracy of Cannabidiol Extracts Sold Online
Marcel O. Bonn-Miller,Mallory J E Loflin,Brian F. Thomas,Jahan P. Marcu,Travis Hyke,Ryan Vandrey +5 more
TL;DR: To maximize sampling and ensure representativeness of available products, this work examined the label accuracy of CBD products sold online, including identification of present but unlabeled cannabinoids.
Journal ArticleDOI
Clinical characteristics and pharmacokinetics of purified soy isoflavones: single-dose administration to healthy men
Marjorie G Busby,A. Robert Jeffcoat,A. Robert Jeffcoat,A. Robert Jeffcoat,LeAnne T Bloedon,LeAnne T Bloedon,LeAnne T Bloedon,Matthew A. Koch,Matthew A. Koch,Matthew A. Koch,Tracy M. Black,Tracy M. Black,Tracy M. Black,Kelly J. Dix,Kelly J. Dix,Kelly J. Dix,William D. Heizer,William D. Heizer,William D. Heizer,Brian F. Thomas,Brian F. Thomas,Brian F. Thomas,Judith Hill,Judith Hill,Judith Hill,James A. Crowell,James A. Crowell,James A. Crowell,Steven H. Zeisel +28 more
TL;DR: Dietary supplements of purified unconjugated isoflavones administered to humans in single doses exceeding normal dietary intake manyfold resulted in minimal clinical toxicity.