John C. Seely

TL;DR: BPA should not be considered a selective reproductive toxicant, based on the results of this study, and no evidence of nonmonotonic dose-response curves across generations for either sex is found.

TL;DR: Dietary bisphenol A was evaluated in a mouse two-generation study and there were no treatment-related effects and no evidence of nonmonotonic dose-response curves for any parameter, therefore, BPA is not considered a selective reproductive or developmental toxicant in mice.

TL;DR: A widely accepted and utilized international harmonization of nomenclature for urinary tract lesions in laboratory animals will decrease confusion among regulatory and scientific research organizations in different countries and provide a common language to increase and enrich international exchanges of information among toxicologists and pathologists.

TL;DR: The offspring toxicity no observable effect level (NOEL) was 750 ppm, based on the presence of reduced AGD in F1 and F2 males at birth at 3750 ppm, but no effects on reproductive development, structures, or functions.

TL;DR: A second-generation, replication-competent adenovirus containing an improved yeast cytosine deaminase (yCD)/mutant(SR39) herpes simplex virus thymidine kinase fusion and ADP genes is developed, providing the scientific basis for evaluating the safety and efficacy of this technology in humans.