M
M R Johnson
Researcher at Research Triangle Park
Publications - 3
Citations - 913
M R Johnson is an academic researcher from Research Triangle Park. The author has contributed to research in topics: Cannabinoid & Bicyclic molecule. The author has an hindex of 3, co-authored 3 publications receiving 891 citations.
Papers
More filters
Journal ArticleDOI
Behavioral, biochemical, and molecular modeling evaluations of cannabinoid analogs.
Billy R. Martin,D R Compton,Brian F. Thomas,W. R. Prescott,P. J. Little,Raj K. Razdan,M R Johnson,L S Melvin,Raphael Mechoulam,S. J. Ward +9 more
TL;DR: The structural diversity and wide-ranging potencies of the analogs described herein provide the opportunity to develop a pharmacophore for the cannabinoids using molecular modeling techniques.
Journal Article
Pharmacology and stereoselectivity of structurally novel cannabinoids in mice.
TL;DR: The pharmacological effects of three stereoisomeric pairs of structurally novel cannabinoids were tested after i.v. administration in mice for depression of spontaneous activity and the production of hypothermia, antinociception and catalepsy to demonstrate the high degree of enantioselectivity and potency.
Journal Article
Pharmacological profile of a series of bicyclic cannabinoid analogs: classification as cannabimimetic agents.
TL;DR: The goals of the studies described herein were to determine whether these bicyclic analogs possess similar pharmacological properties of delta 9-THC, to compare pharmacological activity after s.c. and i.v. administration, and to evaluate the structure-activity relationship of this series of analogs for further insight into cannabinoid mechanism of action.